AUTHOR=Feng Rundong , Patil Suryaji , Zhao Xin , Miao Zhiping , Qian Airong 

TITLE=RNA Therapeutics - Research and Clinical Advancements

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.710738

DOI=10.3389/fmolb.2021.710738

ISSN=2296-889X

ABSTRACT=RNA therapeutics involves the use of coding RNA such as mRNA as well as non-coding RNAs such as small interfering RNAs (siRNA), antisense oligonucleotides (ASO) to target mRNA, aptamers, ribozymes, and clustered regularly interspaced short palindromic repeats-CRISPR-associated (CRISPR/Cas) endonuclease to target proteins and DNA. Due to their diverse targeting ability and research in the RNA modification and delivery systems, it has become possible to develop RNA-based drugs and their investigation in a clinical setting for the treatment of many diseases. Therefore, in this article, we have summarized different RNA therapeutics, their targeting strategies, and clinical progress for various diseases as well as limitations; so that it might help researchers formulate new and advanced RNA therapeutics for various diseases.  Additionally, FDA-approved RNA-based therapeutics have also been discussed.