AUTHOR=Ecsédi Péter , Gógl Gergő , Nyitray László 

TITLE=Studying the Structures of Relaxed and Fuzzy Interactions: The Diverse World of S100 Complexes

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.749052

DOI=10.3389/fmolb.2021.749052

ISSN=2296-889X

ABSTRACT=S100 proteins are non-catalytic small, dimeric, EF-hand Ca2+-binding proteins. Their concentrations are detectably perturbed in cancer growth, metastasis, rheumatic and neurodegenerative diseases. They can control the function of numerous proteins via protein-protein interactions. A good number of these complexes were found to have fuzzy properties. Examining these highly flexible interactions is a difficult task, especially from a structural biology point of view. Here we summarize the suitable in vitro techniques, which could be utilized to gain structural information about these dynamic complexes. We also review what we know about the structures of S100 complexes focusing on their asymmetric nature.