AUTHOR=Xu Hao , Wang Lin 

TITLE=The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.792667

DOI=10.3389/fmolb.2021.792667

ISSN=2296-889X

ABSTRACT=Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and progressive NAFLD can develop into non-alcoholic steatohepatitis (NASH), liver cirrhosis or hepatocellular carcinoma (HCC). NAFLD is a kind of metabolic disordered diseases, which is commonly associated with lipid metabolism, insulin resistance, oxidative stress, inflammation and fibrogenesis, as well as autophagy. Growing studies have shown Notch signaling pathway plays pivotal role int the regulation of  NAFLD progression. Here, we review the profile of the Notch signaling pathway, new evidence of Notch signaling involvement in NAFLD, and describe the potential of Notch as a biomarker and therapeutic target for NAFLD treatment.