AUTHOR=Liu Weiting , Wu Zezhen , Zhu Dan , Chen Genben , Yan Guiming , Zhang Shuo , Chen Fengwu , Khan Barkat Ali , Hou Kaijian 

TITLE=Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.799934

DOI=10.3389/fmolb.2021.799934

ISSN=2296-889X

ABSTRACT=Background and aim: It is known that hyperlipidemia and low vitamin D level are risk factors associated with cardiovascular disease (CVD). However, the effect of vitamin D administration on lipid profiles of postmenopausal women remains unclear. This study aims to evaluate the effect of vitamin D on lipid profiles in postmenopausal women based on meta-analysis and systemic review.
Methods: The literature search was performed in multiple databases (Scopus, PubMed/Medline, Web of Science, and Embase)from 1997 up to 1 May 2021. The statistical analysis was performed using the Stata software version 14 (Stata Corp. College Station, Texas, USA). The effects of vitamin D administration of the lipid profiles, including Triacylglycerol (TG), LDL-Cholesterol(LDL-C), HDL-Cholesterol (HDL-C) and Total Cholesterol( TC) were evaluated by the Der Simonian and Laird random effects model.  The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated.
Results: The level of TG changed significantly by -3.76 mg/dL (CI: -6.12 to -1.39, P=0.000) and HDL-C by 0.48 mg/dL (CI: -0.80 to -0.15, P=0.004) in vitamin D administration group  (11  eligible  trials  (placebo=505 participants,  vitamin  D intervention=604  participants)) compared to the control group in the postmenopausal women. . Taking into account this comparison between groups, in contrast, the level of  LDL-Cholesterol(LDL-C) (WMD: 0.73 mg/dL, 95% CI: -1.88, 3.36, p = 0.583) and TC (WMD: 0.689 mg/dL, CI: -3.059 to 4.438, P=0.719) did not change significantly.
Conclusions: In conclusion, the postmenopausal women vitamin D administration decreased the concentrations of TG and HDL-C, but not of LDL-C and TC.