AUTHOR=Teixeira Cristina , Martins Helena Sofia , Saraiva Maria João 

TITLE=Cellular environment of TTR deposits in an animal model of ATTR—Cardiomyopathy

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1144049

DOI=10.3389/fmolb.2023.1144049

ISSN=2296-889X

ABSTRACT=This animal model of ATTR amyloidosis-cardiomyopathy and associated features observed as result of cardiac TTR deposition provide a promising and invaluable research tool for a better understanding of the implicated pathways that lead to the lethality associated to TTR cardiac amyloidosis. New therapeutic strategies can be tested and ultimately this will lead to improved treatment alternatives capable of increasing patient’s quality of life and life expectancy and, hopefully to eradicate a condition that is silently spreading worldwide.