AUTHOR=Gong Linqiang , Zhao Shiyuan , Chu Xue , Yang Hui , Li Yanan , Wei Shanshan , Li Fengfeng , Zhang Yazhou , Li Shuhui , Jiang Pei 

TITLE=Assessment of cold exposure-induced metabolic changes in mice using untargeted metabolomics

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1228771

DOI=10.3389/fmolb.2023.1228771

ISSN=2296-889X

ABSTRACT=Cold exposure can effectively regulate adipose tissue metabolism. The activation of brown adipose tissue through cold exposure has numerous positive effects on metabolic health. These effects encompass enhanced glucose uptake, improved insulin sensitivity, promoted lipolysis, and reduced levels of triglyceride and cholesterol in the bloodstream. However, certain studies have indicated that cold-induced activation of brown adipose tissue might have adverse health effects, such as an increased heart rate and elevated blood pressure. Therefore, it is crucial to thoroughly examine the impact of cold exposure on the functioning of vital organs in vivo. Previous metabolomics studies have mainly focused on analyzing one or two samples from serum, brown adipose tissue, white adipose tissue, and liver. There is a significant lack of simultaneous analysis of multiple tissues regarding the metabolic changes induced by cold exposure. Therefore, our study aims to investigate the metabolic profiles of the major tissues.