AUTHOR=Dudin Oleksandr , Mintser Ozar , Gurianov Vitalii , Kobyliak Nazarii , Kozakov Denys , Livshun Sofiia , Sulaieva Oksana 

TITLE=Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1543148

DOI=10.3389/fmolb.2025.1543148

ISSN=2296-889X

ABSTRACT=IntroductionAlthough most cutaneous melanoma (CM) in its early stages is treatable, the risk of recurrence remains high and there is a particular ambiguity on patients prognosis. This drives to identification of prognostic biomarkers for predicting CM recurrence to guide appropriate treatment in patients with localized melanoma.AimThis study aimed to develop a prognostic model for assessing the risk of recurrence in patients with CM, enabling prompt prognosis-driven further clinical decision-making for high-risk patients.Materials and methodsThis case-control study included 172 patients with CM recurrence (high-risk group) and 30 patients with stable remission (low-risk group) 3 years after primary diagnosis. The impact of sex, age at diagnosis, anatomical site, histological characteristics (the histological type, pathological stage, ulceration; the depth of invasion, mitotic rate, lymphovascular invasion, neurotropism, association with a nevus, tumor-infiltrating lymphocyte density, tumor regression and BRAF codon 600 mutation status) on CM recurrence was evaluated.ResultsFive independent variables, including nodal status, a high mitotic rate, Breslow thickness, lymphovascular invasion, perineural invasion and regression features were identified as the most significant. A 5-factor logistic regression model was developed to assess the risk of melanoma recurrence. The sensitivity and specificity of the model were 86.1% and 72.7%, respectively.ConclusionThe developed model, which relies on routine histological features, allows the identification of individuals at high risk of CM recurrence to tailor their further management.