AUTHOR=Wister Andrew , Pinigina Elizaveta , Liang Jie , Linkov Igor 

TITLE=AI-enabled resilience modeling for brain health

JOURNAL=Frontiers in Molecular Medicine

VOLUME=Volume 5 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/molecular-medicine/articles/10.3389/fmmed.2025.1671337

DOI=10.3389/fmmed.2025.1671337

ISSN=2674-0095

ABSTRACT=One development in the growing field of Alzheimer’s Disease and related neurological disorders (ADRD) is the consideration of brain resilience, the ability to respond to and recover from adversity, which builds on a growing literature on the role of lifestyle behaviours in ADRD prevention and response. This paper reviews definitions of ‘brain health’ and integrates these with innovations in resilience system models applied to ADRD. Based on a socio-ecological framework that links physiological, behavioral, economic, and social determinants of mental health, we propose a unified model of resilience and aging in this field. We contend that applications of a resilience analytical approach to brain health require innovation in Artificial Intelligence (AI) to harness the full potential of immense interdisciplinary data mining opportunities. These include: development of digital twins, precision health analytics, AI sensors, and Multimodal Large Language Models (MLLM), knowledge graph technologies, and cognitive/decision science modeling. We apply this model to research and clinical examples to elucidate its potential value, requirements, risks, and challenges in developing new research agendas.