AUTHOR=Ritter McKenzie L. , Guo Wei , Samuels Jack F. , Wang Ying , Nestadt Paul S. , Krasnow Janice , Greenberg Benjamin D. , Fyer Abby J. , McCracken James T. , Geller Daniel A. , Murphy Dennis L. , Knowles James A. , Grados Marco A. , Riddle Mark A. , Rasmussen Steven A. , McLaughlin Nicole C. , Nurmi Erika L. , Askland Kathleen D. , Cullen Bernadette , Piacentini John , Pauls David L. , Bienvenu Joseph , Stewart Evelyn , Goes Fernando S. , Maher Brion , Pulver Ann E. , Mattheisen Manuel , Qian Ji , Nestadt Gerald , Shugart Yin Yao 

TITLE=Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 10 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00083

DOI=10.3389/fnmol.2017.00083

ISSN=1662-5099

ABSTRACT=<p><bold>Objective:</bold> The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders.</p><p><bold>Methods:</bold> A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; <italic>p</italic>-values for the protein-protein interaction analysis was calculated using permutation.</p><p><bold>Conclusion:</bold> None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.</p>