AUTHOR=Bartholome Odile , Van den Ackerveken Priscilla , Sánchez Gil Judit , de la Brassinne Bonardeaux Orianne , Leprince Pierre , Franzen Rachelle , Rogister Bernard 

TITLE=Puzzling Out Synaptic Vesicle 2 Family Members Functions

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 10 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00148

DOI=10.3389/fnmol.2017.00148

ISSN=1662-5099

ABSTRACT=Synaptic vesicle proteins 2 (SV2) were discovered in the early eighties, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of synaptic vesicles. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, schizophrenia, Alzheimer’s or Parkinson’s disease. In this review, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.