AUTHOR=Wells Cameron , Brennan Samuel E. , Keon Matt , Saksena Nitin K. 

TITLE=Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 12 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00271

DOI=10.3389/fnmol.2019.00271

ISSN=1662-5099

ABSTRACT=There is a growing body of evidence that prion-like protein behaviours are a core element of neurodegenerative diseases (NDs) that afflict humans. Common elements in pathogenesis, pathological effects and protein-level behaviours exist between Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and Amyotrophic Lateral Sclerosis. These extend beyond the affected neurons to glial cells and processes. This results in a complicated system of disease progression, which often takes advantage of protective processes to promote propagation of pathological protein aggregates. This review provides a current snapshot of knowledge on these proteins and their intrinsic role in the pathogenesis and disease progression seen across NDs.