AUTHOR=Heinrichs Björn , Liu Baowen , Zhang Jin , Meents Jannis E. , Le Kim , Erickson Andelain , Hautvast Petra , Zhu Xiwen , Li Ningbo , Liu Yi , Spehr Marc , Habel Ute , Rothermel Markus , Namer Barbara , Zhang Xianwei , Lampert Angelika , Duan Guangyou TITLE=The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations JOURNAL=Frontiers in Molecular Neuroscience VOLUME=Volume 14 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.709228 DOI=10.3389/fnmol.2021.709228 ISSN=1662-5099 ABSTRACT=
Apart from the most prominent symptoms in Autism spectrum disorder (ASD), namely deficits in social interaction, communication and repetitive behavior, patients often show abnormal sensory reactivity to environmental stimuli. Especially potentially painful stimuli are reported to be experienced in a different way compared to healthy persons. In our present study, we identified an ASD patient carrying compound heterozygous mutations in the voltage-gated sodium channel (VGSC) Na