AUTHOR=Huang Xinying , Jiang Junjian , Xu Jianguang 

TITLE=Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 14 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.810919

DOI=10.3389/fnmol.2021.810919

ISSN=1662-5099

ABSTRACT=Neuromuscular junctions (NMJs) are key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation related NMJs changes limits the recovery level of nerve repair strategies. Insights into mechanisms behind neuromuscular junctions degeneration and regeneration following denervation and reinnervation are of clinical values. Developing some therapies to maintain or protect structures and functions of neuromuscular junctions maybe contributes to a better prognosis. 
Here, we reviewed previous studies of neuromuscular junctions focusing on the morphological, functional and molecular changes after denervation and if those changes can be reversed after reinnervation. Also, we reviewed about present probable strategies that have been applied clinically or still be studied that targeting the neuromuscular junctions protection or regeneration improvement.