AUTHOR=Yang Yijian , Wang Chuansen , Chen Rui , Wang Yuchang , Tan Changwu , Liu Jingping , Zhang Qinghua , Xiao Gelei 

TITLE=Novel therapeutic modulators of astrocytes for hydrocephalus

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 15 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.932955

DOI=10.3389/fnmol.2022.932955

ISSN=1662-5099

ABSTRACT=Hydrocephalus is a functional disorder of cerebrospinal fluid that causes ventricular dilation and intracranial hypertension. Astrocytes are the key response cells to the inflammation in the central nervous system. In hydrocephalus, astrocytes are activated and show a dual character depending on the period of development of the disease. They can suppress the disease in the early stage and may aggravate it in the late stage. More evidence suggests that therapeutics targeting astrocytes may be promising for hydrocephalus. In this review, based on the previous studies, we summarize different forms of hydrocephalus-induced astrocyte reactivity and the corresponding function of these responses in hydrocephalus and also discuss the therapeutic effects of astrocytes regulation on hydrocephalus in experimental studies.