AUTHOR=Zhang Wei-Jun , Shi Hou-Zhen , Guo Mei-Na , Xu Long-Fei , Zhai Hong-Ru , Liu Zi-Zhong , Zhu Yong-Qiang , Zhang Wei-Ning , Wang Jia TITLE=PGC-1α regulates critical period onset/closure, mediating cortical plasticity JOURNAL=Frontiers in Molecular Neuroscience VOLUME=Volume 16 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1149906 DOI=10.3389/fnmol.2023.1149906 ISSN=1662-5099 ABSTRACT=Peroxisome proliferator activated receptor PPAR coactivator-(PGC-1 ) is concentrated in inhibitory interneurons and plays a vital role in neuropsychiatric diseases. We previously reported GABAergic neuron-specific Pgc-1alpha knockout (KO) mice (Dlx5/6-Cre: Pgc-1alpha f/f ) presented some characteristic features of schizophrenia (SZ). However, there is a fundamental gap of the molecular mechanism by which Pgc-1alpha gene involved in the neurobehavioral abnormalities of SZ. Loss of critical period (CP) triggers-maturations of parvalbumin interneurons (PVIs) and brakes-formation of perineuronal nets (PNNs) implicates mistimed trajectories during adult brain development. Here, using the Pgc-1alpha KO mouse line, we investigated the effect of PGC-1 on developmental trajectories to SZ and confirmed Pgc-1alpha gene deletion resulted a failure of CP onset and closure, therefore prolonged cortical plasticity timing. PNN development and maintenance is necessary for regulating PVI function and closing CP plasticity window, a manipulation of PNN structure is a potential way to alter neuronal plasticity. For this to be practicable, GM6001, a broad-spectrum matrix metalloproteinase (MMP)-inhibitor was applied and we confirmed the treatment could effectively corrected CP plasticity window and meliorated synaptic ultrastructure in Pgc-1alpha KO brain. Besides, the intervention effect on neuronal plasticity was followed by rescuing short-term habituation deficits and aberrant salience, some characteristic features of SZ. Taken collectively, these findings suggest that the role of PGC-1 in regulating cortical plasticity is mediated, at least partially through regulating critical period onset/closure. Strategically-introduced reinforcement of molecular brakes may be a novel preventive therapy for psychiatric disorders associated with PGC-1 dysregulation.