AUTHOR=Bhattacharya Reshmee , Alam Mohammad Rizwan , Kamal Mohammad Azhar , Seo Kyung Jin , Singh Laishram Rajendrakumar 

TITLE=AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 16 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1155175

DOI=10.3389/fnmol.2023.1155175

ISSN=1662-5099

ABSTRACT=Advanced glycating end products (AGEs) (e.g., glyoxal, methylglyoxal or carboxymethyl-lysine) are heterogenous group of toxic compounds primarily generated when proteins are exposed to reducing sugars. AGEs also interact with their receptor, receptor for AGE (RAGE) and such interactions influence different biological processes. Previously, AGE-RAGE axis has long been considered to be the maligning factor for various human diseases including, diabetes, obesity, cardiovascular, aging etc. Recent developments have revealed the involvement of AGE-RAGE axis in different pathological consequences associated with neurodegeneration including, disruption of blood brain barrier, neuroinflammation, remodeling of extracellular matrix, dysregulation of polyol pathway and antioxidant enzymes etc. In the present article we attempted to describe a new avenue that AGE-RAGE axis culminates to different pathological consequences in brain and therefore, is a central instigating component to several neurodegenerative diseases. We also invoke that specific inhibitors of TIR domains of TLR or RAGE receptors are crucial molecules for the therapeutic intervention of neurodegenerative diseases. Clinical perspectives have also been appropriately discussed.