Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Mini Review

Published on 01 Apr 2025

Neurotrophic factor alpha 1 gene therapy in Alzheimer’s disease: scope and advancements

in Brain Disease Mechanisms

Ammara Shaikh
Fairus Ahmad
Seong Lin Teoh
Jaya Kumar
Mohamad Fairuz Yahaya

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1518868

5,723 views
6 citations

Original Research

Published on 24 Mar 2025

The serum proteomic profile in patients with migraine

in Brain Disease Mechanisms

Yating Han
Yuan Wang
Xiajuan Zou
Huailian Guo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1460403

2,689 views
3 citations

Original Research

Published on 21 Mar 2025

Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice

in Brain Disease Mechanisms

Cara J. Westmark

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1520211

3,246 views
1 citation

Mini Review

Published on 19 Mar 2025

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

in Brain Disease Mechanisms

Xiaoxin Chen
Qing Cheng
Guo-Fang Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1499376

5,806 views
4 citations

Original Research

Published on 04 Mar 2025

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

in Brain Disease Mechanisms

Elaine K. Hebda-Bauer
Megan H. Hagenauer
Daniel B. Munro
Peter Blandino
Fan Meng
Keiko Arakawa
John D. H. Stead
Apurva S. Chitre
A. Bilge Ozel
Pejman Mohammadi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1469467

3,596 views
1 citation

Original Research

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

in Brain Disease Mechanisms

Menekse Oeztuerk
Diran Herebian
Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
Tobias Ruck

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1548255

3,295 views
1 citation

Original Research

Published on 19 Feb 2025

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

in Brain Disease Mechanisms

Dong Bin Back
Bo-Ryoung Choi
Kyoung Ja Kwon
Dong-Hee Choi
Chan Young Shin
Jongmin Lee
Hahn Young Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1516265

4,203 views
1 citation

Opinion

Published on 18 Feb 2025

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

in Brain Disease Mechanisms

Jacob Peedicayil
Samuel Santhosh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1534569

2,937 views
3 citations

Original Research

Published on 13 Feb 2025

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

in Brain Disease Mechanisms

Brett A. McGregor
Md. Obayed Raihan
Afrina Brishti
Junguk Hur
James E. Porter

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1544971

1,833 views
1 citation

Review

Published on 11 Feb 2025

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

in Brain Disease Mechanisms

Sean D. Fraser
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1550863

4,478 views

Original Research

Published on 05 Feb 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R. Bangash
Zachary M. Chbihi
Sokol V. Todi
Peter A. LeWitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

3,315 views
4 citations

Original Research

Published on 05 Feb 2025

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

in Brain Disease Mechanisms

L. Caccialupi Da Prato
A. Rezzag Lebza
A. Consumi
M. Tessier
A. Srinivasan
C. Rivera
J. Laurin
C. Pellegrino

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1522571

2,386 views
1 citation

Original Research

Published on 29 Jan 2025

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

in Brain Disease Mechanisms

Rodrigo Moraga-Amaro
Oscar Moreno
Jordi Llop
Marion Bankstahl
Jens P. Bankstahl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1488261

3,129 views
2 citations

Review

Published on 27 Jan 2025

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

in Brain Disease Mechanisms

Mitsuharu Hattori

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1546083

4,870 views
6 citations

Original Research

Published on 15 Jan 2025

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

4,266 views

Review

Published on 14 Jan 2025

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

in Brain Disease Mechanisms

Yinyin Xie
Wenlin Sun
Aoya Han
Xinru Zhou
Shijie Zhang
Changchang Shen
Yi Xie
Cui Wang
Nanchang Xie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1527013

6,185 views
3 citations

Editorial

Published on 13 Jan 2025

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

in Brain Disease Mechanisms

Nawab John Dar
David Soriano Castell
Shahnawaz Ali Bhat
Pamela Maher

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1547301

2,398 views

Original Research

Published on 10 Jan 2025

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

in Brain Disease Mechanisms

Nalaka Wijekoon
Lakmal Gonawala
Pyara Ratnayake
Darshana Sirisena
Harsha Gunasekara
Athula Dissanayake
Dhammika Amaratunga
Harry W. M. Steinbusch
Yetrib Hathout
Eric P. Hoffman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1482999

3,477 views
2 citations

Original Research

Published on 10 Jan 2025

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

in Brain Disease Mechanisms

Rasha M. Alderbi
Mohammad Z. Alam
Badrah S. Alghamdi
Hadeil M. Alsufiani
Gamal S. Abd El-Aziz
Ulfat M. Omar
Maryam A. Al-Ghamdi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1503396

3,566 views
1 citation

Review

Published on 07 Jan 2025

Genetic and molecular mechanisms of hydrocephalus

in Brain Disease Mechanisms

Xuehai Deng
Yiqian Chen
Qiyue Duan
Jianlin Ding
Zhong Wang
Junchi Wang
Xinlong Chen
Liangxue Zhou
Long Zhao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512455

5,800 views
2 citations

Review

Published on 24 Dec 2024

The role of Aha1 in cancer and neurodegeneration

in Brain Disease Mechanisms

Brian S.J. Blagg
Kevin C. Catalfano

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1509280

2,777 views
1 citation

Original Research

Published on 20 Dec 2024

Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models

in Brain Disease Mechanisms

Zhenping Gong
Wan Wang
Ying Zhao
Yadan Wang
Ruihua Sun
Haohan Zhang
Fengyu Wang
Yaru Lu
Jiewen Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1391040

3,272 views
2 citations

Original Research

Published on 18 Dec 2024

Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance

in Brain Disease Mechanisms

Bárbara Guerra Leal
Cláudia Carvalho
Cristina Santos
Raquel Samões
Ricardo Martins-Ferreira
Catarina Teixeira
Diana Rodrigues
Joel Freitas
Carolina Lemos
Rui Chorão

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512860

2,364 views
2 citations

Original Research

Published on 12 Dec 2024

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

in Brain Disease Mechanisms

Temuulen Erdenebat
Yusuke Komatsu
Nozomi Uwamori
Misaki Tanaka
Takashi Hoshika
Takeshi Yamasaki
Ayano Shimakura
Akio Suzuki
Toyotaka Sato
Motohiro Horiuchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1498142

3,429 views
1 citation

1,115 articles

articles

Neurotrophic factor alpha 1 gene therapy in Alzheimer’s disease: scope and advancements

The serum proteomic profile in patients with migraine

Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

Genetic and molecular mechanisms of hydrocephalus

The role of Aha1 in cancer and neurodegeneration

Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models

Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice