AUTHOR=Khan Abujunaid Habib , Phan Chin-Soon 

TITLE=Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024

JOURNAL=Frontiers in Natural Products

VOLUME=Volume 4 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1616031

DOI=10.3389/fntpr.2025.1616031

ISSN=2813-2602

ABSTRACT=Macrocyclic compounds have emerged in the 21st century, among which cyclic peptides are of particular interest. Cyanobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs), many of which exist as cyclic peptides with a prenyl moiety, and prenylation can improve their structural stability and biological activity. This mini-review highlights the recently discovered cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Cyanobactin prenyltransferases will allow access to unique prenylated natural products for applications in drug discovery.