AUTHOR=Cuadrado-Payán Elena , Montagud-Marrahi Enrique , Casals-Urquiza Joaquim , del Risco-Zevallos Jimena , Rodríguez-Espinosa Diana , Cacho Judit , Arana Carolt , Cucchiari David , Ventura-Aguiar Pedro , Revuelta Ignacio , Piñeiro Gaston J. , Esforzado Nuria , Cofan Frederic , Bañon-Maneus Elisenda , Campistol Josep M. , Oppenheimer Federico , Torregrosa Josep-Vicens , Diekmann Fritz 

TITLE=Outcomes in older kidney recipients from older donors: A propensity score analysis

JOURNAL=Frontiers in Nephrology

VOLUME=Volume 2 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2022.1034182

DOI=10.3389/fneph.2022.1034182

ISSN=2813-0626

ABSTRACT=Background: the age of patients referred for kidney transplantation has increased progressively. However, the precise influence of age on transplant outcomes is controversial. 

Methods: retrospective study in which graft and recipient survival were assessed in a cohort of ≥75 years old kidney recipients and compared with a contemporary younger one aged 60-65 years through a propensity score analysis. 

Results: we included 106 recipients between 60-65 and 57 patients of ≥75 years old with a median follow-up of 31 [13-54] months. Unadjusted one- and five-year recipient survival did not significantly differ between the older (91% and 74%) and the younger group (95% and 82%, P=0.06). In the IPTW weighted Cox regression analysis, recipient age was not associated with an increased risk of death (HR 1.88 95%CI [0.81-4.37], P=0.14). Unadjusted one- and five-year death-censored graft survival did not significantly differ between both groups (96% and 83% for the older and 99% and 89% for the younger group, respectively, P=0.08). After IPTW weighted Cox Regression analysis, recipient age ≥75 years was no associated with an increased risk of graft loss (HR 1.95, 95%CI [0.65-5.82], P=0.23). 

Conclusions: these results suggest that recipient age should not be considered itself as an absolute contraindication for kidney transplant