AUTHOR=Kurihara Shigekazu , Sawa Naoki , Sumida Keiichi , Ikuma Daisuke , Oba Yuki , Mizuno Hiroki , Sekine Akinari , Yamanouchi Masayuki , Hasegawa Eiko , Suwabe Tatsuya , Urakami Shinji , Kono Kei , Kinowaki Keiichi , Ohashi Kenichi , Yamaguchi Yutaka , Ubara Yoshifumi 

TITLE=A case report of dipeptidyl peptidase 4 inhibitor-related kidney disease combined with renal cancer

JOURNAL=Frontiers in Nephrology

VOLUME=Volume 4 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2024.1409098

DOI=10.3389/fneph.2024.1409098

ISSN=2813-0626

ABSTRACT=A kidney biopsy was performed in a 64-year-old woman with type 2 diabetes mellitus and less than 1 g of proteinuria who rapidly progressed to end-stage renal failure after approximately 2 years of treatment with two dipeptidyl peptidase 4 (DPP-4) inhibitors for type 2 diabetes mellitus. The biopsy revealed not only a coincidental diagnosis of renal cell carcinoma, which was not evident on pre-biopsy computed tomography, but also severe thrombotic microangiopathy (TMA)-like glomerular endothelial cell damage in the noncancerous areas. These results suggest that DPP4 inhibitors may have been involved in two kidney diseases.