AUTHOR=Joharapurkar Amit , Pandya Vrajesh , Patel Harilal , Jain Mukul , Desai Ranjit 

TITLE=Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia

JOURNAL=Frontiers in Nephrology

VOLUME=Volume 4 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2024.1459425

DOI=10.3389/fneph.2024.1459425

ISSN=2813-0626

ABSTRACT=Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the treatment of anemia associated with chronic kidney disease (CKD). This review summarizes the preclinical and clinical profile of desidustat which led to its approval and clinical use in India.