https://www.frontiersin.org/journals/nephrology/sections/glomerular-disease RSS Feed for Glomerular disease section in the Frontiers in Nephrology journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-14T13:34:26.628+00:00 60 https://www.frontiersin.org/articles/10.3389/fneph.2026.1772736 https://www.frontiersin.org/articles/10.3389/fneph.2026.1772736 2026-03-03T00:00:00Z Case Report Andreia Rita HenriquesJoão VendaEmanuel FerreiraNuno OliveiraHelena Sá 1g/24 h and hypoalbuminemia, the patient received OBZ (1 g × 2 doses, two weeks apart). Two months later, she achieved complete remission (proteinuria 0.2 g/24 h, serum albumin 3.7 g/dL), with sustained B-cell depletion and no adverse events. A repeat administration of OBZ (1 g) was performed 10 months later due to B-cell repopulation, rising proteinuria (0.6 g/24 h), and mild hypoalbuminemia (serum albumin 3.4 g/dL), successfully re-inducing complete remission (proteinuria 0.2 g/24 h, serum albumin 3.8 g/dL).DiscussionThis case illustrates the potential of OBZ as an effective therapeutic option in podocytopathies with RTX inadequate response. The superior efficacy of OBZ may result from enhanced antibody-dependent cellular cytotoxicity, depletion of tissue-resident B cells, and reduced immunogenicity compared with RTX. OBZ may thus offer an alternative in refractory MCD/FSGS.]]> https://www.frontiersin.org/articles/10.3389/fneph.2026.1648950 https://www.frontiersin.org/articles/10.3389/fneph.2026.1648950 2026-02-27T00:00:00Z Original Research Danny Thieny TaingBruno VogtLaila-Yasmin Mani https://www.frontiersin.org/articles/10.3389/fneph.2026.1747678 https://www.frontiersin.org/articles/10.3389/fneph.2026.1747678 2026-02-13T00:00:00Z Review Edward J. FilipponeJohn L. Farber https://www.frontiersin.org/articles/10.3389/fneph.2025.1744454 https://www.frontiersin.org/articles/10.3389/fneph.2025.1744454 2026-01-09T00:00:00Z Brief Research Report John J. SimNancy T. CannizzaroQiaoling ChenSasikiran NunnaMohit MathurCibele Pinto 5 ml min−1 1.73 m−2 per year). The composite kidney outcome occurred at 73.3 events per 1,000 patient-years, with a median time to event of 2.8 years and a median age at event of 46 years.ConclusionHispanic/Latinx patients with IgAN demonstrate rapid kidney function decline and early-onset kidney failure. These findings underscore the need for earlier detection and targeted management in this underserved group.]]> https://www.frontiersin.org/articles/10.3389/fneph.2025.1722582 https://www.frontiersin.org/articles/10.3389/fneph.2025.1722582 2026-01-07T00:00:00Z Systematic Review Ankit ShahManish MaskiOgo EgbunaWhitney LongstaffJanice Stricker-ShaverBeth Barber https://www.frontiersin.org/articles/10.3389/fneph.2025.1715546 https://www.frontiersin.org/articles/10.3389/fneph.2025.1715546 2025-12-09T00:00:00Z Original Research Xiaoyun LiGuoxiang YaoYujiao SunNa LiCaifeng GaoHaiping WangRong WangBing Chen https://www.frontiersin.org/articles/10.3389/fneph.2025.1678502 https://www.frontiersin.org/articles/10.3389/fneph.2025.1678502 2025-11-24T00:00:00Z Systematic Review Aolat Adepeju AdepojuMubarak Abubakar MuhammadMubashir Mayowa AdamsonShakirudeen Abdulqodri AdewaleAdedeji Tayyib AdekunleLekan Sheriff OjulariAbdullateef Isiaka Alagbonsi https://www.frontiersin.org/articles/10.3389/fneph.2025.1673799 https://www.frontiersin.org/articles/10.3389/fneph.2025.1673799 2025-11-21T00:00:00Z Case Report Abhisekh Sinha RayPraveen ErrabelliMaulik LathiyaNeeharik Mareedu https://www.frontiersin.org/articles/10.3389/fneph.2025.1667619 https://www.frontiersin.org/articles/10.3389/fneph.2025.1667619 2025-10-02T00:00:00Z Case Report Mariana León-PóoEva López-MeleroAmir ShabakaCarmen Guerrero-MárquezMaría Barcenilla-LópezClara Cases-CoronaEnrique GrussDeborah Roldán https://www.frontiersin.org/articles/10.3389/fneph.2025.1653595 https://www.frontiersin.org/articles/10.3389/fneph.2025.1653595 2025-09-18T00:00:00Z Opinion Emre LeventoğluBahar BüyükkaragözSevcan A. Bakkaloğlu https://www.frontiersin.org/articles/10.3389/fneph.2025.1667652 https://www.frontiersin.org/articles/10.3389/fneph.2025.1667652 2025-09-10T00:00:00Z Brief Research Report Lina León-MachadoGonzalo Sierra-TorresAmir ShabakaClara Cases-CoronaCristina VegaBegoña RivasDiana Ruiz CabreraGema Fernandez-Juarez https://www.frontiersin.org/articles/10.3389/fneph.2025.1591512 https://www.frontiersin.org/articles/10.3389/fneph.2025.1591512 2025-09-02T00:00:00Z Case Report Justin David TseJackson WangAdarsh BhatRajib Kumar Gupta https://www.frontiersin.org/articles/10.3389/fneph.2025.1594639 https://www.frontiersin.org/articles/10.3389/fneph.2025.1594639 2025-08-26T00:00:00Z Case Report Dongli QiRicong YuQijun WanYi Xu https://www.frontiersin.org/articles/10.3389/fneph.2025.1593927 https://www.frontiersin.org/articles/10.3389/fneph.2025.1593927 2025-06-30T00:00:00Z Case Report Lucille Jane WilkinsonSally StauderBrady CulpepperJalal IbrahimVivekanand PantangiPrathap Kumar Simhadri https://www.frontiersin.org/articles/10.3389/fneph.2025.1599316 https://www.frontiersin.org/articles/10.3389/fneph.2025.1599316 2025-06-16T00:00:00Z Original Research Daniel EnosMariel HernándezGonzalo P. MéndezLysis CáceresIgnacia BravoJosefina JobetSimón CastroLorena CornejoCatalina VegaAndrés Salazar https://www.frontiersin.org/articles/10.3389/fneph.2025.1548679 https://www.frontiersin.org/articles/10.3389/fneph.2025.1548679 2025-04-29T00:00:00Z Original Research Baike MaoJiahui HanJia WangKan Ye https://www.frontiersin.org/articles/10.3389/fneph.2025.1574239 https://www.frontiersin.org/articles/10.3389/fneph.2025.1574239 2025-04-24T00:00:00Z Original Research Giancarlo PesceMit PatelGaelle GustoAnanth KadambiAastha ChandakTerri Madison https://www.frontiersin.org/articles/10.3389/fneph.2025.1542475 https://www.frontiersin.org/articles/10.3389/fneph.2025.1542475 2025-04-01T00:00:00Z Case Report Jonathan MarquezLauren O’SullivanAudrey E. SquireGinny L. RyanKatherine E. DebiecAnne-Marie Amies OelschlagerMargaret P. Adam C; p. =) of uncertain significance that is also present in her similarly affected mother. To help clarify the potential impact of this variant, we completed a mini-gene assay to detect in vitro splicing changes in the presence of the WT1 variant sequence uncovered in this individual. This demonstrated resultant aberrant splicing that further supports the pathogenicity of the uncovered variant for this individual.ConclusionsTo our knowledge, this represents the first case of a podocytopathy with co-occurring uterovaginal anomalies due to exon skipping in WT1. The patient exhibited a severe course of chronic kidney dysfunction requiring a kidney transplant. Clinical RNA sequencing to clarify variants impacting splicing remains challenging due to tissue- specific gene expression for genes such as WT1, thus, research-based assays may be beneficial to understand the consequence of rare or previously uncharacterized variants.]]> https://www.frontiersin.org/articles/10.3389/fneph.2025.1545329 https://www.frontiersin.org/articles/10.3389/fneph.2025.1545329 2025-02-04T00:00:00Z Review Edward J. FilipponeRakesh GulatiJohn L. Farber https://www.frontiersin.org/articles/10.3389/fneph.2025.1519481 https://www.frontiersin.org/articles/10.3389/fneph.2025.1519481 2025-01-23T00:00:00Z Brief Research Report Suryanarayanan BalakrishnanCharat ThongprayoonIasmina M. CraiciWisit CheungpasitpornJing Miao