AUTHOR=Ballout Nissrine , Frappé Isabelle , Péron Sophie , Jaber Mohamed , Zibara Kazem , Gaillard Afsaneh TITLE=Development and Maturation of Embryonic Cortical Neurons Grafted into the Damaged Adult Motor Cortex JOURNAL=Frontiers in Neural Circuits VOLUME=Volume 10 - 2016 YEAR=2016 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2016.00055 DOI=10.3389/fncir.2016.00055 ISSN=1662-5110 ABSTRACT=
Injury to the human central nervous system can lead to devastating consequences due to its poor ability to self-repair. Neural transplantation aimed at replacing lost neurons and restore functional circuitry has proven to be a promising therapeutical avenue. We previously reported in adult rodent animal models with cortical lesions that grafted fetal cortical neurons could effectively re-establish specific patterns of projections and synapses. The current study was designed to provide a detailed characterization of the spatio-temporal