AUTHOR=Berger Daniel R. , Seung H. Sebastian , Lichtman Jeff W. TITLE=VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks JOURNAL=Frontiers in Neural Circuits VOLUME=Volume 12 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2018.00088 DOI=10.3389/fncir.2018.00088 ISSN=1662-5110 ABSTRACT=Recent developments in serial-section electron microscopy allow the efficient generation of very large image data sets but analyzing such data poses challenges for software tools. Here we introduce VAST, a freely available utility program for generating and editing annotations and segmentations of large volumetric image (voxel) data sets. It provides a simple yet powerful user interface for real-time exploration and analysis of large data sets even in the Petabyte range.