AUTHOR=Croizier Sophie , Chometton Sandrine , Fellmann Dominique , Risold Pierre-Yves TITLE=Characterization of a mammalian prosencephalic functional plan JOURNAL=Frontiers in Neuroanatomy VOLUME=Volume 8 - 2014 YEAR=2015 URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2014.00161 DOI=10.3389/fnana.2014.00161 ISSN=1662-5129 ABSTRACT=

Hypothalamic organizational concepts have greatly evolved as the primary hypothalamic pathways have been systematically investigated. In the present review, we describe how the hypothalamus arises from a molecularly heterogeneous region of the embryonic neural tube but is first differentiated as a primary neuronal cell cord (earliest mantle layer). This structure defines two axes that align onto two fundamental components: a longitudinal tractus postopticus(tpoc)/retinian component and a transverse supraoptic tract(sot)/olfactory component. We then discuss how these two axonal tracts guide the formation of all major tracts that connect the telencephalon with the hypothalamus/ventral midbrain, highlighting the existence of an early basic plan in the functional organization of the prosencephalic connectome.