AUTHOR=Sun Qian , Chen Guan-Qun , Wang Xi-Bin , Yu Ying , Hu Yu-Chuan , Yan Lin-Feng , Zhang Xin , Yang Yang , Zhang Jin , Liu Bin , Wang Cong-Cong , Ma Yi , Wang Wen , Han Ying , Cui Guang-Bin 

TITLE=Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment

JOURNAL=Frontiers in Neuroanatomy

VOLUME=Volume 12 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2018.00021

DOI=10.3389/fnana.2018.00021

ISSN=1662-5129

ABSTRACT=<b>Aims:</b> To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively.
<b>Methods:</b> Twelve T2DM patients without MCI and twenty-four age, sex, and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (FA, MD, λ<sub>1</sub>, and λ<sub>23</sub>) and FC measurement was performed to calculate hippocampal FC with other brain regions. Cognitive function was evaluated by using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Brain volumes were also evaluated among these participants.
<b>Results:</b> There were no difference of MMSE and MoCA scores between two groups. Neither whole brain nor regional brain volume decrease was revealed in T2DM patients without MCI. DTI analysis revealed extensive WM disruptions, especially in the body of corpus callosum. Significant decreases of hippocampal FC with certain brain structures were revealed, especially with the bilateral frontal cortex. Furthermore, the decreased FA in left posterior thalamic radiation and increased MD in the splenium of corpus callosum were closely related with the decreased hippocampal FC to caudate nucleus and frontal cortex.
<b>Conclusions:</b> T2DM patients without MCI showed extensive WM disruptions and abnormal hippocampal FC. Moreover, the WM disruptions and abnormal hippocampal FC were closely associated.