AUTHOR=Boeken Ole Jonas , Markett Sebastian 

TITLE=Systems-level decoding reveals the cognitive and behavioral profile of the human intraparietal sulcus

JOURNAL=Frontiers in Neuroimaging

VOLUME=Volume 1 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroimaging/articles/10.3389/fnimg.2022.1074674

DOI=10.3389/fnimg.2022.1074674

ISSN=2813-1193

ABSTRACT=The human intraparietal sulcus (IPS) covers large portions of the posterior cortical surface and has been implicated in a variety of cognitive functions. It is, however, unclear how cognitive functions dissociate between the IPS’s heterogenous subdivisions, particularly in perspective to their connectivity profile. We applied a neuroinformatics driven system-level decoding on three cytoarchitectural distinct subdivisions (hIP1, hIP2, hIP3) per hemisphere, with the aim to disentangle the cognitive profile of the IPS in conjunction with functionally connected cortical regions. The system-level decoding revealed nine functional systems based on meta-analytical associations of IPS subdivisions and their cortical coactivations: Two systems - working memory and numeric cognition - which are centered on all IPS subdivisions, and seven systems - attention, language, grasping, recognition memory, rotation, detection of motions/shapes and navigation – with varying degrees of dissociation across subdivisions and hemispheres. By probing the spatial overlap between systems-level co-activations of the IPS and seven canonical intrinsic resting state networks, we observed a trend towards more co-activation between hIP1 and the frontoparietal network, between hIP2 & hIP3 and the dorsal attention network, and between hIP3 and the visual and somatomotor network. Our results confirm previous findings on the IPS’s role in cognition but also point to previously unknown differentiation along the IPS, which present viable starting points for future work. We also present the systems-level decoding as promising approach towards functional decoding of the human connectome.