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        <title>Frontiers in Neuroimaging | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/neuroimaging</link>
        <description>RSS Feed for Frontiers in Neuroimaging | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-08T06:05:07.983+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1691870</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1691870</link>
        <title><![CDATA[Imaging research, diagnosis, and treatment advances of post-stroke cognitive impairment]]></title>
        <pubdate>2026-05-04T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Mengyi Huang</author><author>Qunbo Jia</author><author>Yushu Ouyang</author><author>Xiaoteng Feng</author><author>Ronghui Ju</author>
        <description><![CDATA[Post-stroke cognitive impairment (PSCI) has garnered widespread attention due to its high incidence and its association with increased risk of stroke recurrence and mortality. Growing evidence indicates that early prediction of PSCI and the implementation of effective interventions can help delay disease progression and improve long-term patient outcomes. With advances in imaging technology, the role of neuroimaging has evolved from traditional anatomical localization to a multimodal assessment system that integrates macrostructural, microstructural connectivity, and molecular metabolic information. Imaging features can serve as objective and reproducible quantitative indicators, sensitively capturing subtle pathological changes in brain tissue, thereby providing a reliable basis for clinical diagnosis, treatment strategy formulation, and prevention. This review systematically summarizes recent research progress in the clinical diagnosis and imaging characteristics of PSCI. It focuses on analyzing the impact and underlying mechanisms of specific biomarkers, gene expression, cerebral small vessel disease, and cerebral perfusion abnormalities on cognitive function, and further explores the application prospects of advanced imaging technologies in the assessment of PSCI.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1753534</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1753534</link>
        <title><![CDATA[Anatomically constrained volumetric smoothing enhances fMRI reliability while avoiding smoothing artifacts]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>David G. Ellis</author><author>Michele R. Aizenberg</author>
        <description><![CDATA[IntroductionSmoothing fMRI data prior to analysis is a fundamental and widely used technique to increase sensitivity. Unconstrained smoothing can also reduce the spatial specificity of the analysis by introducing artifacts in the data. This study tested the effects of smoothing on the reliability and accuracy of both task fMRI and resting state data. The effects of unconstrained smoothing were compared to those of an anatomically constrained smoothing method, which prevents smoothing across the white and gray matter surfaces of the cortex.MethodsUnconstrained Gaussian smoothing and anatomically constrained smoothing were applied to simulated data, a sensory task fMRI dataset, a precision fMRI motor task mapping dataset, and a resting state fMRI dataset. Smoothing-related artifacts were tested for and compared between the smoothing methods, and the effects of the smoothing methods on the reliability and accuracy were measured.ResultsIn the experiments with simulated data, unconstrained Gaussian smoothing demonstrated decreased accuracy and increased white matter activation compared to constrained smoothing. In the sensory task activation analysis, both Gaussian and constrained smoothing increased the reliability of the sensory task fMRI activations, but Gaussian smoothing increased the percentage of active voxels in the white matter relative to constrained smoothing (p < 0.001). Relative to constrained smoothing, Gaussian smoothing with FWHM > 3 mm also decreased the accuracy of motor mapping results from individual sessions to the precision maps (p < 0.001). With cluster significance thresholding, mean false positive voxel percentages remained below 5% for both methods across the tested kernel widths. Both Gaussian and constrained smoothing demonstrated a biasing effect on the resting state connectivity of nearby regions and on the graph theory metrics of the functional connectomes.ConclusionThis study showed that unconstrained Gaussian smoothing spreads activation across cortical boundaries, increases white matter activation, and biases graph theory connectivity metrics. Anatomically constrained smoothing reduced some of these smoothing artifacts while still increasing reliability and may be a reasonable alternative to unconstrained Gaussian smoothing.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1776934</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1776934</link>
        <title><![CDATA[Gadolinium-based contrast agent-free (GBCA-free) versus gadolinium-based contrast agent-enhanced (GBCA-enhanced) magnetic resonance imaging as a screening tool for intracranial tumors]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Haider Faeq Hadhratee Al-Rubaiee</author><author>Samr Adnan Abdaljabbar Al-Salm</author><author>Weronika Jensen</author><author>Agnieszka Monika Delekta</author><author>Yousef Yavarian</author><author>Boris Modrau</author>
        <description><![CDATA[BackgroundGBCA-enhanced MRI is considered the gold standard for diagnosing intracranial tumors. However, concerns regarding gadolinium-based contrast agents (GBCAs) and workflow limitations have led to increasing interest in GBCA-free MRI techniques.ObjectiveTo compare the diagnostic performance of GBCA-free MRI with GBCA-enhanced MRI for detecting intracranial tumors within a neurological diagnostic pathway.MethodsIn this retrospective cohort study, 191 patients with 195 tumors (124 intra-axial and 71 extra-axial) and 410 controls were included from a regional brain tumor diagnostic pathway between 2013 and 2022. Three senior neuroradiologists independently assessed anonymized MRI scans. Each scan was first evaluated using GBCA-free sequences and subsequently reassessed using the full GBCA-enhanced protocol. Sensitivity, specificity, and inter-method agreement were calculated.ResultsGBCA-free MRI demonstrated a sensitivity of 79.6% and a specificity of 96.1%, whereas GBCA-enhanced MRI showed a sensitivity of 73.3% and a specificity of 92.9% (p = 0.15). Agreement between the two imaging approaches was substantial (κ = 0.699). Subgroup analyses showed comparable performance for intra-axial tumors, while both imaging approaches demonstrated modest sensitivity for extra-axial tumors.ConclusionGBCA-free MRI demonstrated diagnostic performance comparable to that of GBCA-enhanced MRI for detecting intracranial tumors. These findings suggest that GBCA-free MRI may serve as a reliable first-line screening tool within the neurological diagnostic pathway, reserving GBCA administration for cases requiring further lesion characterization.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1818662</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1818662</link>
        <title><![CDATA[Benchmarking functional brain network organization in childhood and its similarity to adults]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Sana A. Ali</author><author>Damion V. Demeter</author><author>Abigail R. Baim</author><author>Emily M. Koithan</author><author>Matthew Feigelis</author><author>Salma Zreik</author><author>Jonathan Ahern</author><author>Sarah E. Chang</author><author>Sujin Park</author><author>Evan M. Gordon</author><author>Scott Marek</author><author>Deanna J. Greene</author>
        <description><![CDATA[Understanding how large-scale functional networks mature across development is essential for linking brain organization to cognition and behavior. Thus, the population-level organization of functional networks in children and how it compares to adult network architecture deserves further study. Using resting-state fMRI data from 7,316 children aged 9–10 years in the Adolescent Brain Cognitive Development (ABCD) Study, we mapped functional networks in matched discovery (n = 3,624) and replication (n = 3,692) cohorts in the cerebral cortex, basal ganglia, thalamus, and cerebellum. Functional connectivity and network topography were highly reproducible across child cohorts, demonstrating that large-scale network organization can be reliably estimated in childhood at the population scale. Comparisons with the adult Human Connectome Project (HCP; n = 1,000) dataset revealed reduced cross-age similarity compared to the within-age similarity. Our findings indicate that by late childhood, the global scaffold of brain networks approximates adult architecture with continued refinement, particularly in higher-order association systems. This large-scale, discovery–replication framework establishes a reproducible benchmark for cross-age functional network mapping, providing a foundation for longitudinal analyses of maturation across adolescence.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1796824</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1796824</link>
        <title><![CDATA[Investigating white matter functional network connectivity across the Alzheimer’s disease spectrum using resting-state fMRI]]></title>
        <pubdate>2026-04-23T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Vaibhavi S. Itkyal</author><author>Theodore J. LaGrow</author><author>Kyle M. Jensen</author><author>Armin Iraji</author><author>Vince D. Calhoun</author>
        <description><![CDATA[White matter (WM) has traditionally been considered structurally important but functionally inert in fMRI research. However, growing evidence indicates that WM exhibits meaningful BOLD fluctuations and participates in functional connectivity. Here, we investigate alterations in WM functional network connectivity (FNC) across the Alzheimer’s disease (AD) spectrum using resting-state fMRI data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI; 415 cognitively normal (CN), 283 mild cognitive impairment (MCI), 91 AD). We applied a guided independent component analysis (ICA) approach based on a combined multiscale template including 202 intrinsic connectivity networks [ICNs; 97 WM, 105 gray matter (GM)] to estimate subject-specific timecourses and compute FNC. Group differences in WM–WM, GM–GM, and WM–GM functional network connectivity (AD–CN, AD–MCI, MCI–CN) were evaluated using two-sample t-tests on residual FNC values for age, sex, and mean framewise displacement. Multiple comparisons across edges were controlled using false discovery rate correction (q < 0.05), and effect sizes were quantified using Hedges’ g. Results showed robust alterations in WM–WM and WM–GM connectivity in AD, particularly involving WM subcortical, frontal, sensorimotor, and occipitotemporal networks. Several WM–GM interactions with cerebellar and hippocampal GM networks were also disrupted, including reduced GM–cerebellar: WM–frontal coupling and increased GM–hippocampal: WM–frontal connectivity. Notably, MCI already showed WM–GM dysconnectivity relative to CN, suggesting that functional disruption of WM circuits emerges prior to overt dementia. These findings provide converging evidence that WM functional connectivity is both measurable and selectively altered across the AD continuum. Our findings support WM FNC as a candidate biomarker to GM-based measures for staging and monitoring AD. Together, these results position WM–GM dysconnectivity as an important systems-level signature of the AD continuum and support WM functional network connectivity as a promising complement to established GM-based measures for understanding disease progression.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1771087</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1771087</link>
        <title><![CDATA[Opposite sides of different coins: near-diametrical opposition of physiological indices of reduced accuracy of face emotion recognition in schizophrenia and autism spectrum disorders]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Daniel C. Javitt</author><author>Antigona Martinez</author><author>Pejman Sehatpour</author><author>Pamela D. Butler</author><author>Elisa Dias</author><author>Kristin Micceri</author><author>Melissa Breland</author><author>Russell H. Tobe</author>
        <description><![CDATA[BackgroundSchizophrenia (Sz) and autism spectrum disorder (ASD) are associated with reduced accuracy offace emotion recognition (FER). Nevertheless, the underlying pathophysiological mechanisms may diverge, potentially related to differential processing patterns within the early visual system. Here, we investigated physiological-level responses to emotional faces. We hypothesized that Sz and ASD would be associated with convergent behavioral performance, but divergent pathophysiological mechanisms.Study designSimultaneous eye-tracking and continuous EEG data were obtained from 23 adults diagnosed with schizophrenia (Sz), 21 autistic adults, and 24 neurotypical controls (NC) in response to intact and chimeric emotion faces. Event-related potentials (ERP) were calculated from the ongoing EEG data using time- and time-frequency (TF) domain approaches. Symptoms were rated using the Positive and Negative Symptom Scale (PANSS) and the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) in Sz and ASD, respectively.Study resultsAs predicted, Sz and ASD were associated with similar levels of reduced FER accuracy relative to NC, but differential patterns of eye tracking and EEG-related activity. Rates of eye- vs. mouth-fixations were reduced across groups but did not correlate with FER. Nevertheless, the ability to utilize eye-information diverged across groups. Thus, when viewing chimeric faces, Sz was associated with reduced tendency to utilize eye information and increased tendency to utilize mouth information even when fixation location was considered. In TF analyses, reduced FER accuracy was associated with reduced initial sensory responses in Sz, as reflected in the theta-band time-frequency response. In contrast, in ASD, reduced FER accuracy was associated with increased alpha-frequency event-related desynchronization (alpha-ERD) consistent with hyper-engagement of secondary visual regions (V2). A combination of physiological and eye-tracking measures differentiated schizophrenia and ASD with >90% accuracy. V2 hyper-engagement in ASD correlated with both reduced FER accuracy and ADOS Social Interaction domain scores.ConclusionSchizophrenia and ASD are associated with divergent physiological-level alterations within the early visual system during emotional face processing, supporting models of magnocellular visual hypoactivity in schizophrenia but retinotectal visual hyperactivity leading to hyper-engagement of non-face regions (V2) by face stimuli in ASD. These alterations, in turn, may serve as targets for future intervention studies related to social cognition.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1756394</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1756394</link>
        <title><![CDATA[Neural correlates of Sudoku play: a systematic review of brain imaging studies]]></title>
        <pubdate>2026-04-20T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Morgan J. Williams</author><author>Ellie J. Williamson</author><author>Samantha Jane Brooks</author>
        <description><![CDATA[IntroductionSudoku is a popular logic-based puzzle that requires sustained attention, working memory, and rule-based reasoning. Despite its widespread use, the neural processes supporting Sudoku play have not been systematically synthesised, limiting understanding of its potential applications beyond leisure.MethodsThis systematic review aimed to examine the neural correlates of Sudoku solving and to evaluate its potential relevance as a cognitive training paradigm. Six neuroimaging studies were included (five fMRI, and one fNIRS).ResultsAcross haemodynamic studies, Sudoku solving consistently engaged frontoparietal networks, including the dorsolateral prefrontal cortex (DLPFC) and parietal regions implicated in executive control and visuospatial working memory, alongside activation of the anterior cingulate cortex (ACC), associated with performance monitoring and cognitive control.DiscussionThe included fNIRS study provided converging evidence of increased prefrontal activation during Sudoku solving under more ecologically valid conditions. Together, these findings suggest that Sudoku play recruits distributed neural systems supporting cognitive control, monitoring, and memory processes. While the limited number and heterogeneity of studies preclude firm conclusions regarding efficacy, the observed neural engagement highlights Sudoku as a candidate task for probing executive function and self-regulatory processes in both healthy and clinical populations.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1814006</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1814006</link>
        <title><![CDATA[Physical, cognitive, and psychosocial fatigue are differently related to cortical complexity of superior temporal and frontal brain regions in Crohn’s disease]]></title>
        <pubdate>2026-04-16T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Theresa A. McIver</author><author>Charles N. Bernstein</author><author>Ruth Ann Marrie</author><author>John D. Fisk</author><author>Chase R. Figley</author><author>Jennifer Kornelsen</author>
        <description><![CDATA[IntroductionFatigue is common in persons with Crohn’s disease, negatively impacting quality of life in both active and remitted disease state. Neural correlates of fatigue in Crohn’s disease are understudied, particularly relative to the separate impacts of physical, cognitive, and psychosocial fatigue. The potential moderating role of cortical complexity on the relationship between disease activity and fatigue has yet to be examined.MethodsForty-nine participants with Crohn’s disease and 49 healthy control participants completed the Fatigue Impact Scale (which includes physical, cognitive, and psychosocial subscales) and whole-brain T1-weighted magnetic resonance imaging. Cortical complexity analyses were performed in CAT12, including within- and between-group analyses.ResultsIn the Crohn’s disease group, greater fatigue across all domains was associated with lower cortical complexity in the right superior temporal gyrus. Physical and cognitive impacts of fatigue were differently related to cortical complexity in the superior frontal and supramarginal gyri. Cortical complexity in the healthy control group was exclusively, positively, related to the physical impact of fatigue. The relationship between disease activity and fatigue varied relative to cortical complexity in the right superior temporal gyrus (ΔR2 = 0.062, F = 5.558, p = 0.023) and the right superior frontal gyrus (ΔR2 = 0.058, F = 4.059, p = 0.050).DiscussionThe present findings expand our understanding of the complex brain-gut interactions linking disease activity and fatigue in Crohn’s disease relative to underlying differences in cortical complexity.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1811399</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1811399</link>
        <title><![CDATA[Electroconvulsive therapy modulates Fronto-temporal functional connectivity in adolescents with depression and suicidal ideation]]></title>
        <pubdate>2026-04-10T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Xiaolu Chen</author><author>Jianmei Chen</author><author>Ming Ai</author><author>Su Hong</author><author>Linxi Dai</author><author>Xiaoshan Shen</author><author>Li Kuang</author>
        <description><![CDATA[ObjectiveWe aimed to investigate changes in whole-brain functional connectivity (FC) before and after electroconvulsive therapy (ECT) in adolescents with major depressive disorder (MDD) and suicidal ideation (SI).MethodsForty-nine adolescents with MDD and SI were enrolled, and resting-state functional magnetic resonance imaging (rs-fMRI) was performed at baseline and after ECT for each patient. Forty healthy controls (HCs) were scanned only at baseline. Region-of-interest (ROI)-based whole-brain FC analyses were used, with the left superior frontal gyrus (L-SFG) and right superior temporal gyrus (R-STG) as seed regions.ResultsCompared with HCs, MDD patients at baseline showed decreased FC between R-STG and left inferior occipital gyrus (L-IOG), and between L-SFG and right anterior cingulate gyrus (R-ACG). After ECT, MDD patients showed reduced FC between R-STG and right middle temporal gyrus (R-MTG), increased FC between L-SFG and right middle frontal gyrus (R-MFG), and decreased FC between L-SFG and right superior occipital gyrus (R-SOG)/right superior frontal gyrus (R-SFG). Pearson’s correlation found that post-ECT Hamilton Depression Rating Scale-17 (HAMD-17) scores were negatively correlated with FC between R-STG and L-IOG.ConclusionAbnormal FC in the frontal-cingulate and frontal-temporal circuits may be a potential neurobiological basis of depressive and suicidal symptoms in adolescents. ECT may improve these symptoms by modulating FC in these key brain regions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1783329</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1783329</link>
        <title><![CDATA[Hypereosinophilic syndrome with central nervous system involvement: a case report]]></title>
        <pubdate>2026-04-08T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Wenjuan Xu</author><author>Chao Zhang</author><author>Fan Wang</author><author>Xiaomin Liu</author><author>Xiao Zhang</author><author>Fei Mao</author><author>Xinyi Wang</author><author>Xiaoyu Zhang</author>
        <description><![CDATA[Cerebral infarction is the most common neurological complication in patients with hypereosinophilic syndromes (HES), typically occurring in border-zone regions. However, intracranial artery stenosis is rarely observed in HES, and the underlying mechanisms of cerebral infarction remain largely unknown. Here, we report a case of HES complicated by acute ischemic stroke secondary to severe stenosis of left middle cerebral artery (MCA). A diagnosis of idiopathic HES was established based on eosinophilia (14.08%) in bone marrow aspiration and negative genetic testing. Without contraindications, intravenous thrombolysis with alteplase was administered, resulting in a decrease of the National Institutes of Health Stroke Scale score from 13 to 2. High-resolution magnetic resonance imaging (HR-MRI) showed homogeneous, concentric wall thickening and enhancement in the terminal segments of the left internal carotid artery and at the origin of the MCA, indicating an inflammatory process. Follow-up HR-MRI at 17 months demonstrated a reduction in vessel wall enhancement after immunosuppressive therapy. Over the two-year follow-up period, the eosinophil count remained within the range of 0.22–1.09 × 109/L, and no stroke recurrence was observed. In the literature review, only three cases of stroke associated with HES reported intracranial stenosis, all located in the M1 segment of the MCA. Their clinical outcomes improved following immunosuppressive therapy. Thus, intracranial large artery stenosis is a rare etiology of stroke in patients with HES. Homogeneous vessel wall enhancement on HR-MRI suggests an underlying vasculitis, which appears responsive to immunosuppressive therapy.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1736950</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1736950</link>
        <title><![CDATA[Comparison of commercial 1Tx32Rx vs. 8Tx32Rx head coils for routine 7T neuroimaging]]></title>
        <pubdate>2026-03-25T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Carina Graf</author><author>Belinda Ding</author><author>Catarina Rua</author><author>Krzysztof Klodowski</author><author>Christopher T. Rodgers</author>
        <description><![CDATA[IntroductionHuman 7T MRI systems are manufactured by three vendors (Siemens, Philips, and GE) who all provide equivalent head coils from the same 3rd party manufacturer. Furthermore, many 7T MRI sites have two head coils available for neuroimaging: a 1Tx32Rx head coil for conventional single-channel transmit imaging and an 8Tx32Rx head coil for parallel-transmit (pTx) imaging.MethodsWe compared the performance of these coils in six healthy volunteers. All scans were done on a 7T MRI (MAGNETOM Terra, Siemens, Germany). We tested seven sequences in wide use at our centre: B0 and B1+ mapping, anatomical T1-weighted MP2RAGE, R2*-mapping, single-voxel spectroscopy (MRS), echo-planar imaging time series, and diffusion tensor imaging (DTI). Sequences were run unmodified and without any pTx pulses.ResultsData quality is comparable for both coils. The 8Tx32Rx coil had improved B1+ in inferior brain regions, enhanced spinal cord visibility in the cervical spine on anatomical MP2RAGE, higher SNR in MRS of the brainstem, and more defined fitted white matter tracts in the DTI images. All sequences showed acceptable data quality with the 8Tx32Rx coil.ConclusionIt is reasonable to substitute the 8Tx32Rx coil for the 1Tx32Rx coil for standard neuroimaging protocols. This will enable advanced parallel transmit sequences to be added to protocols with minimal disruption.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1816667</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1816667</link>
        <title><![CDATA[Retraction: Initial insights into post-contrast enhancement in ultra-low-field MRI: Case Report]]></title>
        <pubdate>2026-03-11T00:00:00Z</pubdate>
        <category>Retraction</category>
        
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1751864</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1751864</link>
        <title><![CDATA[Unique presentation of superficial siderosis of the central nervous system following pituitary tumor surgery: a case report and literature review]]></title>
        <pubdate>2026-02-26T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Tengyao Liang</author><author>Jiangqin Song</author><author>Fengzhu Zhao</author><author>Weifang Zhu</author><author>Hui Wei</author>
        <description><![CDATA[Superficial Siderosis of the Central Nervous System is an infrequent neurological disorder resulting from hemosiderin deposition due to chronic and recurrent subarachnoid hemorrhage, leading to significant neurological impairments including sensorineural hearing loss, cerebellar ataxia, and pyramidal signs. This case report presents a 50-year-old male patient with a history of pituitary tumor surgery, manifesting progressive neurological symptoms over 2 years, thereby highlighting the potential long-term complications associated with SSCNS. The atypical clinical presentation, coupled with a surgical background, underscores the diagnostic challenges faced by clinicians, who may misattribute symptoms to more common neurological conditions. Advanced imaging modalities, particularly susceptibility-weighted imaging (SWI), have proven essential in enhancing the diagnostic accuracy for SSCNS, revealing characteristic patterns of iron deposition that are often subtle and can lead to delayed recognition. This case not only contributes to the existing literature by documenting a rare presentation of SSCNS but also emphasizes the necessity for increased awareness and vigilance among healthcare providers regarding this condition’s complex manifestations. The findings advocate for interdisciplinary collaboration between neurologists and radiologists to improve recognition and management strategies, ultimately leading to better patient outcomes. Despite the rarity and variability of SSCNS, which complicates the establishment of standardized treatment protocols, this case highlights the critical need for continued research into its underlying mechanisms and therapy efficacy, particularly in patients with previous neurological interventions. Enhanced educational initiatives may be pivotal in addressing the diagnostic challenges associated with this debilitating condition.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1670604</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1670604</link>
        <title><![CDATA[Diffusion MRI sampling schemes bias diffusion metrics and tractography]]></title>
        <pubdate>2026-02-25T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ivanei Bramati</author><author>Diego Szczupak</author><author>Marina Carneiro Monteiro</author><author>Fernanda Meireles</author><author>Daniel Menezes Guimarães</author><author>Ryan J. Dean</author><author>Lynn K. Paul</author><author>Fernanda Tovar-Moll</author>
        <description><![CDATA[IntroductionDiffusion MRI is increasingly used to study white-matter architecture, but tractography and diffusion metrics can be biased by different sampling schemes. We assessed systematic differences across four common protocols—single-shell high-angular resolution diffusion imaging (HARDI), Siemens clinical multi-shell (Sms), diffusion spectrum imaging (DSI), and Human Connectome Project multi-shell (HCPms)—in healthy adults and individuals with corpus callosum dysgenesis (CCD).MethodsAll data were acquired on a single 3 T scanner and processed uniformly to extract fractional anisotropy (FA), mean diffusivity (MD), effective contrast-to-noise ratio (eCNR), and orientation dispersion within the corpus callosum (CC), corona radiata (CR), and centrum semiovale (CSO). In controls, we measured tract volumes for CC, bilateral CR, anterior commissure (AC) and posterior commissure (PC), and streamline counts for AC and PC; in CCD, we quantified volumes of the Probst and sigmoid bundles.ResultsAcross participants, FA and MD showed moderate cross-scheme correlations for most ROIs, but matched means were rare (only Sms–HARDI in CC). eCNR and dispersion exhibited few cross-scheme correlations; however, means were similar for eCNR between Sms and HCPms and for dispersion among HARDI, DSI, and HCPms. Tract-based volumes correlated across Sms, DSI, and HCPms for CC in controls and for the right sigmoid and both Probst bundles in CCD. DSI and HCPms yielded similar volumes in all ROIs (controls and CCD). In controls, Sms volumes agreed with DSI/HCPms in CR, but were lower in CC and in all CCD ROIs. HARDI produced higher volumes in CC and bilateral CR in controls and in all CCD ROIs. For AC and PC in controls, tract-based means (volumes, streamlines, streamlines/volume) were consistent across schemes; nonetheless, correlations were limited—streamlines and streamlines/volume correlated for Sms, DSI, and HARDI in AC, and for DSI and HCPms in PC.DiscussionThese findings demonstrate systematic differences in voxel-wise metrics and tractography outcomes from four diffusion-sampling schemes. In addition to qualitatively informing attempts to consolidate or contrast data across schemes, future work could explore regression-based harmonization—and other methods—to reduce residual bias and enable pooled analyses across diverse protocols.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2025.1688973</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2025.1688973</link>
        <title><![CDATA[Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI]]></title>
        <pubdate>2026-02-18T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Bradley J. MacIntosh</author><author>S. Shirley Lin</author><author>Finn O’Hara</author><author>Nathan W. Churchill</author><author>Fred Tam</author><author>Alexandra Pavel</author><author>Eugenie Roudaia</author><author>Allison B. Sekuler</author><author>Ivy Cheng</author><author>Fuqiang Gao</author><author>Benjamin Lam</author><author>Chris Heyn</author><author>Mario Masellis</author><author>J. Jean Chen</author><author>Tom A. Schweizer</author><author>Sandra E. Black</author><author>Simon J. Graham</author>
        <description><![CDATA[BackgroundCoronavirus disease 2019 (COVID-19) has been associated with central nervous system dysfunction implicating cerebrovascular and neurovascular units, as reflected in lower regional cerebral blood flow among non-hospitalized individuals that experienced post COVID-19 condition (PCC). This study investigates whether PCC is associated with altered regional cerebral blood volume assessed using Dynamic Susceptibility Contrast (DSC) Magnetic Resonance Imaging (MRI). The comparison control group are individuals without PCC who previously experienced cold or flu-like symptoms, or COVID-19.MethodsFifty-seven participants were recruited: 36 with PCC (mean age: 42.7, standard deviation: 10.4, 26 females) and 21 controls (mean age: 41.6, standard deviation: 14.7, 13 females). T2*-weighted DSC MRI was performed at 3 Tesla to image the first passage of the bolus. A total of 22 regions of interest (ROIs) were considered. Group differences in DSC-derived cerebral blood volume (rCBV) and cerebral blood flow (rCBF) were evaluated using Bayesian regression, providing median group differences, highest density interval (HDI), and the probability of direction (PD) estimates.ResultsThe two groups (PCC and controls) were matched for age, sex, days from symptom onset, and number of previous vaccines, but had different degrees of self-report illness severity. The rCBV analysis showed median group differences (range: −0.05 to −0.13), with PD > 0.90, indicating a high probability of decreased rCBV in the PCC group, involving the superior frontal gyrus, thalamus, paracentral lobule, cingulate gyrus, postcentral gyrus, middle frontal gyrus, inferior frontal gyrus, and superior temporal gyrus ROIs. By comparison, group differences in rCBF were muted and did not reach PD > 0.90.DiscussionWe found group-level differences that were reflected by lower regional rCBV in PCC relative to controls. The imaging findings are suggestive of cerebrovascular alterations several months after the initial illness.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1746464</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1746464</link>
        <title><![CDATA[A systematic study on the integration of MRI connectivity metrics for Alzheimer's diagnosis, staging, and cognitive decline prediction]]></title>
        <pubdate>2026-02-17T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Shahzad Ali</author><author>Wendy Kreshpa</author><author>Nicola Rosso</author><author>Michele Piana</author><author>Luca Roccatagliata</author><author>Alessio Cirone</author><author>Lorenzini Luigi</author><author>Cristina Campi</author><author>Matteo Pardini</author><author>Sara Garbarino</author>
        <description><![CDATA[Alzheimer's disease (AD) is a degenerative neurological disorder marked by cognitive decline and functional disability. Despite the extensive use of magnetic resonance imaging (MRI) in machine learning (ML)-based AD studies, the relative and combined contributions of MRI-derived morphometric (MO), microstructural (MS), and graph-theoretical (GT) features are still not well explored in a unified, comparative framework. It remains unclear whether adding multimodal MRI-derived features consistently improves the predictive performance of ML-based approaches for AD diagnosis and cognitive decline. Addressing this gap, this study systematically analyzed the individual (MO, MS, GT) and combined (MO+MS, MO+GT, MS+GT, MO+MS+GT) utility of MRI-based feature sets. We developed an ensemble-based ML framework with a nested cross-validation module for two key tasks: (i) Alzheimer's disease cognitive stage classification (DSC) and (ii) longitudinal cognitive decline prediction (LCDP) in terms of mini-mental state examination (MMSE) score. In this study, we conducted feature ablation and statistical analysis to evaluate performance improvements resulting from the incremental addition of feature sets. The results of the study indicated that the proposed ensemble-based ML approach achieved the best predictive performance (balanced accuracy [BACC]: 0.898 ± 0.051) using a combination of MO and MS feature sets for cognitively normal (CN) vs. AD dementia (CN–ADD). In contrast, the best results for mild cognitive impairment (MCI) vs. ADD (MCI–ADD) and CN–MCI were achieved using the MO feature set alone, with BACC of 0.769 ± 0.116 and 0.652 ± 0.044, respectively. Likewise, for the LCDP task, the MO-based ensemble learner achieved an R2 of 0.212 ± 0.177. These results demonstrate that MO features capture the most robust disease-related information, while multimodal integration offers task-specific and limited benefits. In addition, these findings demonstrate the potential of integrated MRI-derived features in ML frameworks for enhancing ADD diagnosis and cognitive decline prediction and underscore the importance of feature selection based on task complexity.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1728970</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1728970</link>
        <title><![CDATA[Study protocol for the Champaign-Urbana population study]]></title>
        <pubdate>2026-02-10T00:00:00Z</pubdate>
        <category>Study Protocol</category>
        <author>Paul B. Camacho</author><author>Aaron T. Anderson</author><author>Rong Guo</author><author>Yuhui Chai</author><author>Sina Tafti</author><author>Ian Hall</author><author>Dominika M. Pindus</author><author>Chris Lockwood</author><author>Paul M. Arnold</author><author>Sheeba Arnold-Anteraper</author><author>Zhi-Pei Liang</author><author>Hacene Serrai</author><author>Andrew G. Webb</author><author>Bansari Upadhyay</author><author>Diane Beck</author><author>Mark D. Whiting</author><author>Bruce M. Damon</author><author>Tracey M. Wszalek</author><author>Brad P. Sutton</author>
        <description><![CDATA[Superior signal-to-noise ratio, enhanced and novel forms of contrast, and improved spectral resolution made possible by 7 Tesla (7 T) magnetic resonance imaging (MRI) offer great promise for both neuroimaging research and clinical practice. To characterize these gains, it is essential to acquire structural, functional, and biochemical 7 T MRI data from a large sample of adults. The Champaign Urbana Population Study (CUPS) will collect and publish a database of 7 T MRI data, including raw MRI data, from a cohort of up to 200 adults. Here, we describe the study design and provide example images from the initial round of data collection for CUPS.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2026.1726037</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2026.1726037</link>
        <title><![CDATA[Deep learning to predict future cognitive decline: a multimodal approach using brain MRI and clinical data]]></title>
        <pubdate>2026-02-04T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Tamoghna Chattopadhyay</author><author>Pavithra Senthilkumar</author><author>Rahul H. Ankarath</author><author>Christopher Patterson</author><author>Emma J. Gleave</author><author>Sophia I. Thomopoulos</author><author>Heng Huang</author><author>Li Shen</author><author>Lei You</author><author>Degui Zhi</author><author>Paul M. Thompson</author>
        <description><![CDATA[Predicting the trajectory of clinical decline in aging individuals is a pressing challenge, especially for people with mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, or vascular dementia. Accurate predictions can guide treatment decisions, identify risk factors, and optimize clinical trials. In this study, we compared two deep learning approaches for forecasting changes, over a 2-year interval, in the Clinical Dementia Rating scale ‘sum of boxes’ score (sobCDR), as a continuous outcome (regression). This is a key metric in dementia research and clinical trials, and scores range from 0 (no impairment) to 18 (severe impairment). To predict decline, we trained a hybrid convolutional neural network (CNN) that integrates 3D T1-weighted brain MRI scans with tabular clinical and demographic features (including age, sex, body mass index (BMI), and baseline sobCDR). We benchmarked its performance against AutoGluon, an automated multimodal machine learning framework that selects an appropriate neural network architecture (an ‘autoML’ approach). We evaluated the models using data from 2,319 unique participants drawn from three independent cohorts—ADNI, OASIS-3, and NACC. For each participant, we used one T1-weighted brain MRI scan along with corresponding clinical and demographic information. Our results demonstrate the importance of combining image and tabular data in predictive modeling for this clinical application. Deep learning algorithms can fuse information from image-based brain signatures and tabular clinical data, with potential for personalized prognostics in aging and dementia. Rather than concluding that multimodal fusion uniformly improves performance, our results show that deep learning applied to volumetric MRI data may struggle to add predictive value, particularly when clinical covariates explain substantial variance and provide a strong baseline. In other conditions and tasks, it may help to have a hybrid system that can learn from both data types, and their relative value may be different. Conversely, AutoML-based multimodal fusion provides a robust baseline when tabular data already provide strong predictive value for the task. These insights clarify how different multimodal strategies could be selected in clinical prognostic applications.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2025.1743623</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2025.1743623</link>
        <title><![CDATA[Clinical and radiographic intersection of cerebral amyloid angiopathy with euglycemic diabetic ketoacidosis in the development of transient focal neurologic deficits: case report]]></title>
        <pubdate>2026-01-16T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>John Paul Aboubechara</author><author>Michael Saggio</author><author>Olivia Campa</author><author>Kader Karli Oguz</author><author>Ivy Nguyen</author>
        <description><![CDATA[ObjectivesThis study aimed to describe a case of transient neurologic deficits triggered by euglycemic diabetic ketoacidosis (DKA) in brain tissue at risk due to heavy cerebral amyloid angiopathy (CAA) microbleed burden, while demonstrating the rare imaging finding of reversible T2 fluid-attenuated inversion recovery (FLAIR) subcortical hypointensity.MethodsWe present the clinical course, laboratory findings, and neuroimaging features of an 81-year-old man who presented with acute altered mental status and transient focal neurologic deficits.ResultsThe patient presented with encephalopathy, headache, left hemianopsia, left sensory neglect, and mild left upper extremity weakness. Laboratory examination showed euglycemic DKA. Brain MRI revealed findings consistent with probable CAA according to Boston Criteria 2.0, including innumerable cortical microbleeds predominantly in the right temporo-parieto-occipital lobes, with superimposed diffuse T2 FLAIR-weighted hypointensity in this region.DiscussionReversible T2 FLAIR hypointensity has been described in hyperglycemia-associated syndromes. In this case, T2 FLAIR hypointensity likely represented metabolic dysregulation that triggered cortical dysfunction within brain regions at risk due to heavy CAA-related microbleed burden. We speculate that a common pathway for the development of the patient’s transient deficits resulted from cortical spreading depolarization (CSD), which has been associated with both CAA and hyperglycemia.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fnimg.2025.1659480</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fnimg.2025.1659480</link>
        <title><![CDATA[Neuroimaging evaluation of high dose methotrexate-induced neurotoxicity in pediatric and young adults: a PET/MRI study]]></title>
        <pubdate>2026-01-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Zahra Shokri Varniab</author><author>Hyun Gi Kim</author><author>Ricarda von Krüchten</author><author>Yashas Ullas Lokesha</author><author>Kristina Elizabeth Hawk</author><author>Shashi Bhushan Singh</author><author>Tie Liang</author><author>Sarah Lu-Liang</author><author>Lucia Baratto</author><author>Michael Iv</author><author>Heike Elisabeth Daldrup-Link</author>
        <description><![CDATA[IntroductionHigh-dose Methotrexate (HDMTX) can induce neurotoxicity, yet its impact on brain metabolism remains underexplored. This study aimed to assess short- and long-term brain metabolic changes post-HDMTX on 18F-FDG PET/MRI relative to baseline (pre-HDMTX) scans.MethodsIn this IRB approved, retrospective study, we included 19 children and young adults (3 females and 16 males; age 17.9 ± 4.3 years), with lymphoma (n = 13) or osteosarcoma (n = 6). All patients underwent 18F-FDG PET/MRI before (baseline) and after HDMTX (>1000 mg/m2). Post-treatment scans were conducted ≤3 months (short-term group, n = 11) or >3 months (long-term group, n = 8) after completion of HDMTX and were compared with baseline scans. SUVmean and SUVmax of the whole brain cortex and six subregions were measured with PMOD software. A generalized linear regression model was used to evaluate post-pre-HDMTX SUV values differences in whole cortex with p < 0.05 and for with of different brain subregions, with p < 0.008 after Bonferroni correction.ResultsIn the short-term group, compared with baseline, both SUVmean (pre-HDMTX vs. post-HDMTX: 5.06 ± 1.62 vs. 6.31 ± 1.71, p < 0.001) and SUVmax (9.16 ± 3.33 vs. 13.25 ± 3.35, p < 0.001) significantly increased in the whole cortex following HDMTX. In contrast, the long-term group showed no significant changes in SUVmean (6.31 ± 1.71 vs. 6.30 ± 1.54, p = 0.1) or SUVmax (12.01 ± 3.53 vs. 11.58 ± 3.07, p = 0.1) after HDMTX.Discussion18F-FDG PET/MRI revealed short-term increases in brain metabolism post-HDMTX compared with baseline, possibly reflecting neuroinflammation. Long-term follow up scans revealed normalization of brain metabolism or decreased brain metabolism compared to baseline, the latter possibly indicating neurotoxicity.]]></description>
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