AUTHOR=Li Xin , Liang Huadong TITLE=Project, toolkit, and database of neuroinformatics ecosystem: A summary of previous studies on “Frontiers in Neuroinformatics” JOURNAL=Frontiers in Neuroinformatics VOLUME=Volume 16 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2022.902452 DOI=10.3389/fninf.2022.902452 ISSN=1662-5196 ABSTRACT=In the field of neuroscience, the core of cohort study project consists in the collection, analysis and sharing of multi-modal data. Recent years has witnessed a host of efficient and high-quality toolkits published and employed to improve the quality of multi-modal data in cohort study. In turn, to glean answers to relevant questions from such a huge collection of papers is a time-consuming task for cohort researchers. As part of our efforts to tackle this problem, we propose a hierarchical neuroscience knowledge base that consists of projects/organizations, multi-modal databases and toolkits, so as to facilitate researchers’ answer searching process. We first classified the topics of the articles in Frontiers in Neuroinformatics according to the multi-modal data life cycle, and from these articles extracted such information objects as projects/organizations, multi-modal databases, and toolkits. Then, we map these information objects into our proposed knowledge base framework. A Python-based query tool has also been developed in tandem for quicker access the knowledge base, (accessible at https://github.com/Romantic-Pumpkin/PDT_fninf). Finally, based on constructed knowledge base, we discussed some key research issues and underlying trends in different stages of the multi-modal data life cycle.