AUTHOR=Proshina Ekaterina , Martynova Olga , Portnova Galina , Khayrullina Guzal , Sysoeva Olga 

TITLE=Long-range temporal correlations in resting state alpha oscillations in major depressive disorder and obsessive-compulsive disorder

JOURNAL=Frontiers in Neuroinformatics

VOLUME=Volume 18 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2024.1339590

DOI=10.3389/fninf.2024.1339590

ISSN=1662-5196

ABSTRACT=Mental disorders are a significant concern in contemporary society, with a pressing need to identify biological markers. Long-range temporal correlations (LRTC) of brain rhythms have been widespread in clinical cohort studies, especially in major depressive disorder (MDD). However, research on LRTC in obsessive-compulsive disorder (OCD) is severely limited. Given the high cooccurrence of OCD and MDD, we conducted an LRTC investigation using the 64-channel resting state EEG of 29 MDD participants, 26 OCD participants, and a control group of 37 volunteers. Our results indicate that all scaling exponents of the three subject groups exhibited persistent LRTC of EEG oscillations. There was a tendency for LRTC to be higher in disorders than in controls, but statistically significant differences were found between the OCD and control groups in the entire frontal and left parietal occipital areas, and between the MDD and OCD groups in the middle and right frontal areas. We believe that these results indicate abnormalities in the inhibitory and excitatory neurotransmitter systems, predominantly affecting areas related to executive functions.