AUTHOR=Bersch Domenic , Vilas Martina G. , Saba-Sadiya Sari , Schaumlöffel Timothy , Dwivedi Kshitij , Sartzetaki Christina , Cichy Radoslaw M. , Roig Gemma 

TITLE=Net2Brain: a toolbox to compare artificial vision models with human brain responses

JOURNAL=Frontiers in Neuroinformatics

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2025.1515873

DOI=10.3389/fninf.2025.1515873

ISSN=1662-5196

ABSTRACT=In cognitive neuroscience, the integration of deep neural networks (DNNs) with traditional neuroscientific analyses has significantly advanced our understanding of both biological neural processes and the functioning of DNNs. However, challenges remain in effectively comparing the representational spaces of artificial models and brain data, particularly due to the growing variety of models and the specific demands of neuroimaging research. To address these challenges, we present Net2Brain, a Python-based toolbox that provides an end-to-end pipeline for incorporating DNNs into neuroscience research, encompassing dataset download, a large selection of models, feature extraction, evaluation, and visualization. Net2Brain provides functionalities in four key areas. First, it offers access to over 600 DNNs trained on diverse tasks across multiple modalities, including vision, language, audio, and multimodal data, organized through a carefully structured taxonomy. Second, it provides a streamlined API for downloading and handling popular neuroscience datasets, such as the NSD and THINGS dataset, allowing researchers to easily access corresponding brain data. Third, Net2Brain facilitates a wide range of analysis options, including feature extraction, representational similarity analysis (RSA), and linear encoding, while also supporting advanced techniques like variance partitioning and searchlight analysis. Finally, the toolbox integrates seamlessly with other established open source libraries, enhancing interoperability and promoting collaborative research. By simplifying model selection, data processing, and evaluation, Net2Brain empowers researchers to conduct more robust, flexible, and reproducible investigations of the relationships between artificial and biological neural representations.