AUTHOR=Hardesty Douglas A., Sanai Nader 

TITLE=The Value of Glioma Extent of Resection in the Modern Neurosurgical Era

JOURNAL=Frontiers in Neurology

VOLUME=Volume 3 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2012.00140

DOI=10.3389/fneur.2012.00140

ISSN=1664-2295

ABSTRACT=Objective:  There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection.  Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era.

Methods:  We reviewed every major peer-reviewed clinical publication since 1990 on the role of extent of resection in glioma outcome.

Results:  Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected extent of resection, and survival benefit.

Conclusions:  Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly-diagnosed gliomas.