AUTHOR=Karaca Sibel , Tan Meliha , Tan Uner TITLE=Human quadrupedalism is not an epiphenomenon caused by neurodevelopmental malformation and ataxia JOURNAL=Frontiers in Neurology VOLUME=Volume 3 - 2012 YEAR=2012 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2012.00154 DOI=10.3389/fneur.2012.00154 ISSN=1664-2295 ABSTRACT=Two cases of individuals with quadrupedal locomotion (QL) were presented. In both cases the brains and cognitive functions were normal and no neurological deficits were seen, except for a paralyzed leg in case 2. It was suggested that human QL (i) should not be considered as an epiphenomenon caused by neurodevelopmental malformation and ataxia, but (ii) may be considered as a re-emergence of the ancestral diagonal QL, and (iii) it may spontaneously emerge in humans with entirely normal brains, by taking advantage of neural networks such as central pattern generators that have been preserved for about 400 million years.