AUTHOR=Surpur Spurthi Sunil , Govindarajan Raghav 

TITLE=Role of “Sural Sparing” Pattern (Absent/Abnormal Median and Ulnar with Present Sural SNAP) Compared to Absent/Abnormal Median or Ulnar with Normal Sural SNAP in Acute Inflammatory Demyelinating Polyneuropathy

JOURNAL=Frontiers in Neurology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00512

DOI=10.3389/fneur.2017.00512

ISSN=1664-2295

ABSTRACT=Abstract: 
Background:
Sural sparing defined as absent/abnormal median sensory nerve action potential amplitude (SNAP) or absent/abnormal ulnar SNAP amplitude with a normal sural SNAP amplitude is thought to be a marker for inflammatory demyelinating polyneuropathies. 

Objective:
If sural sparing pattern specifically defined as absent/abnormal median and ulnar SNAP amplitude with normal sural SNAP amplitude (AMUNS) is sensitive and specific as compared to either absent/abnormal median and normal sural (AMNS) or absent/abnormal ulnar and normal sural(AUNS) for AIDP, CIDP and select non-diabetic axonopathies (AX) and diabetic neuropathies (DN).

Method:
Retrospective analysis from 2001-2010 on all newly diagnosed AIDP, CIDP, select non-diabetic axonopathies (AX) and diabetic neuropathies (DN).

Results:
There were 20 AIDP and 23 CIDP. 20 AX and 50 DN patients between 2009 and 2010 were included as controls. AMUNS was seen in 65% of AIDP, 39% CIDP compared with 10% of AX and 6% for DN with sensitivity of 51%, specificity of 92% whereas the specificity of AMNS/AUNS was 73% and its sensitivity was 58%. If a patient has AMUNS they are > 12 times more likely to have AIDP (p < 0.001). 

Conclusion:
Sural sparing (AMUNS) is highly specific but not sensitive as compared to either AMNS or AUNS in AIDP but does not add to sensitivity or specificity in CIDP.