AUTHOR=Gil-Perotin Sara , Castillo-Villalba Jéssica , Carreres-Polo Joan , Navarré-Gimeno Arantxa , Mallada-Frechín Javier , Pérez-Miralles Francisco , Gascón Francisco , Alcalá-Vicente Carmen , Cubas-Nuñez Laura , Casanova-Estruch Bonaventura 

TITLE=Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report

JOURNAL=Frontiers in Neurology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00340

DOI=10.3389/fneur.2018.00340

ISSN=1664-2295

ABSTRACT=The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein, (MOG)-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes (in the neuromyelitis optica spectrum disorders [NMOSD] and less frequently, in multiple sclerosis [MS]), but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG.