AUTHOR=Beeskow Anne B. , Oberstadt Moritz , Saur Dorothee , Hoffmann Karl-Titus , Lobsien Donald 

TITLE=Delayed Post-hypoxic Leukoencephalopathy (DPHL)—An Uncommon Variant of Hypoxic Brain Damage in Adults

JOURNAL=Frontiers in Neurology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00708

DOI=10.3389/fneur.2018.00708

ISSN=1664-2295

ABSTRACT=Delayed post-hypoxic leukoencephalopathy (DPHL) is an uncommon, potentially under-recognized, cause of hypoxia induced white matter injury.  It characteristically follows a biphasic course: After an initial phase of altered neurologic status a recovery occurs which is then followed by a recurring phase of neurologic deterioration, typically 2-4 weeks after the initial event. At this time white matter changes can be identified on MRI, which are the hallmark of DPHL. The characteristics and the typical MR-imaging signs of DPHL are discussed in this case report.