AUTHOR=Jiang Nan , Guan Hongzhi , Lu Qiang , Ren Haitao , Peng Bin TITLE=Features and Prognostic Value of Quantitative Electroencephalogram Changes in Critically Ill and Non-critically Ill Anti-NMDAR Encephalitis Patients: A Pilot Study JOURNAL=Frontiers in Neurology VOLUME=Volume 9 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00833 DOI=10.3389/fneur.2018.00833 ISSN=1664-2295 ABSTRACT=Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common cause of encephalitis in intensive care units. Until now, no reliable method has existed for predicting the outcome of anti-NMDAR encephalitis. In this study, we used quantitative electroencephalography (qEEG) to examine the brain function of anti-NMDAR encephalitis patients and assessed its predictive value. Twenty-six patients diagnosed with anti-NMDAR encephalitis were included and grouped according to whether they were treated in intensive care units (fourteen critically ill vs. twelve non-critically ill). All patients underwent 2-hour 10-channel qEEG recordings at the acute stage. Parameters, including amplitude-integrated electroencephalogram (aEEG), spectral edge frequency 95%, total power, power within different frequency bands (δ, θ, α and β), and percentages of power in specific frequency bands from frontal and parietal areas were calculated with NicoletOne Software and compared between groups. The short-term outcome was death or moderate/severe disability at 3 months after onset, measured with a modified Rankin Scale, and the long-term outcome was death, disability or relapse at 12 months. No differences in qEEG parameters were observed between the critically ill and non-critically ill patients. However, differential anterior-to-posterior alterations in δ and β absolute band power were observed. Logistic regression analysis revealed that a narrower parietal aEEG bandwidth was associated with favorable long-term outcomes (odds ratio, 37.9; P = 0.044), with an optimal cutoff value of 1.7 μV and corresponding sensitivity and specificity of 90.00% and 56.25%, respectively. In a receiver operating characteristic analysis, the area under the curve was 0.7312. In conclusion, the qEEG parameters failed to reflect the clinical severity of anti-NMDAR encephalitis. However, the parietal aEEG bandwidth may separate patients with favorable and poor long-term outcomes in early stages. The underlying mechanisms require further investigation.