AUTHOR=Zhou Chenheng , Liu Keqin , Yan Shenqiang , Jin Ying 

TITLE=Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00008

DOI=10.3389/fneur.2019.00008

ISSN=1664-2295

ABSTRACT=Background: It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtype. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS. 
Methods: We searched EMBASE, PubMed and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed. 
Results: Seven eligible studies including 3218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04 to 2.44; p = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34 to 3.02; p < 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435 to 1.128; p = 0.143).
Conclusions: Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.