AUTHOR=Xu Dingkang , Xu Hongen , Wang Fang , Wang Guoqing , Wei Qingjie , Lei Shixiong , Gao Qiang , Zhang Qi , Guo Fuyou 

TITLE=Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis With Polyangiitis: Case Report and Literature Review

JOURNAL=Frontiers in Neurology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00213

DOI=10.3389/fneur.2019.00213

ISSN=1664-2295

ABSTRACT=Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare rheumatic immune disease characterized by small- and medium-sized blood vessel vasculitis. Central nervous system (CNS) involvement frequently consists of cerebrovascular diseases, whereas a manifestation with multiple lesions and intracerebral occupying effects has never been reported. This report describes a 38-year-old man who presented with progressive deterioration of the memory and underwent microsurgery; EGPA was subsequently confirmed. Unique clinical and radiological features as well as immunohistological outcomes and DNA sequencing revealed a potential disease-associated HLA type, and single nucleotide polymorphisms (SNPs) are described for this uncommon case. Although EGPA rarely involves the CNS, this differential diagnosis should be considered when patients present with a history of nasosinusitis, elevated eosinophil percentage, clinical pulmonitis, and neurological manifestations. Microsurgery is necessary for precise diagnosis and effective treatment.