AUTHOR=Sadighi Alireza , Abedi Vida , Stanciu Alia , El Andary Nada , Banciu Mihai , Holland Neil , Zand Ramin 

TITLE=Six-Month Outcome of Transient Ischemic Attack and Its Mimics

JOURNAL=Frontiers in Neurology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00294

DOI=10.3389/fneur.2019.00294

ISSN=1664-2295

ABSTRACT=Background & Objective: Although the risk of recurrent cerebral ischemia is higher after a transient ischemic attack (TIA), there is limited data on the outcome of TIA mimics. The goal of this study is to compare the 6-month outcome of patients with negative and positive diffusion-weighted imaging (DWI) TIAs (DWI-neg TIA vs. DWI-pos TIA) and also TIA mimics.
Methods: We prospectively studied consecutive patients with an initial diagnosis of TIA in our tertiary stroke centers in a two-year period. Every included patient had an initial magnetic resonance (MR) with DWI and one-month, three, and six-month follow-up visits. The primary outcome was defined as the composition of intracerebral hemorrhage, ischemic stroke, TIA, coronary artery disease, and death.
Results: Out of 269 patients with the initial diagnosis of TIA, 259 patients (mean age 70.5 ± 15.0 [30-100] years old, 56.8% men) were included in the final analysis. 21 (8.1%, 95% confidence interval [CI] 5.1-12.1%) patients had a composite outcome event within the 6-month follow-up. Five (23.8%) and 13 (61.9%) composite outcome events occurred in the first 30 and 90 days, respectively. Among patients with DWI-neg TIA, the one-month and six-month ischemic stroke rate was 1.5% and 4.6%, respectively. The incidence proportion of composite outcome event was significantly higher among patients who had the diagnosis of DWI-neg TIA compared with those who had the diagnosis of TIA mimics (12.2% vs. 2.1% - relative risk 5.9; 95% CI, 1.4 - 25.2). In our univariable analysis among patients with DWI-neg TIA and DWI-pos TIA, age (P=0.017) was the only factor that was significantly associated with the occurrence of the composite outcome. 
Conclusion: Our study indicated that the overall six-month rate of the composite outcome among patients DWI-neg TIA, DWI-pos TIA, and TIA mimics were 12.2%, 9.7%, and 2.1%, respectively. Age was the only factor that was significantly associated with the occurrence of the composite outcome.