AUTHOR=Fukai Ryoko , Takahashi Keita , Abe Hiroyuki , Higashiyama Yuichi , Doi Hiroshi , Takeuchi Hideyuki , Tanaka Fumiaki 

TITLE=Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00763

DOI=10.3389/fneur.2019.00763

ISSN=1664-2295

ABSTRACT=<p>Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients.</p>