AUTHOR=Roccella Michele , Marotta Rosa , Operto Francesca Felicia , Smirni Daniela , Precenzano Francesco , Bitetti Ilaria , Messina Giovanni , Sessa Francesco , Di Mizio Giulio , Loreto Carla , Salerno Monica , Russo Vincenzo , Murabito Paolo , Gallai Beatrice , Esposito Maria , Iacono Diego , Carotenuto Marco 

TITLE=NREM Sleep Instability in Pediatric Migraine Without Aura

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00932

DOI=10.3389/fneur.2019.00932

ISSN=1664-2295

ABSTRACT=<p>Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; <italic>p</italic> ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) (<italic>p</italic> = 0.008). In particular, MoA children showed a reduced CAP rate% (<italic>p</italic> ≤ 0.001), CAP rate% in S1 (<italic>p</italic> ≤ 0.001) and CAP rate% in SWS (<italic>p</italic> = 0.004) vs. C. Moreover, A phases distribution were characterized by a reduction in slow wave components (total number CAP A1%, CAP A1 index) (<italic>p</italic> ≤ 0.001) and an increase of fast components representation (total number of CAP A2% and CAP A3%) (<italic>p</italic> &lt; 0.001) in MoA vs. C. Moreover, MoA children showed an increased A1 and A2 mean duration (<italic>p</italic> ≤ 0.001). Our findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.</p>