AUTHOR=Cai Lun , He Qianchao , Lu Yongjing , Hu Yuying , Chen Wei , Wei Liping , Hu Yueqiang 

TITLE=Comorbidity of Pain and Depression in a Lumbar Disc Herniation Model: Biochemical Alterations and the Effects of Fluoxetine

JOURNAL=Frontiers in Neurology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01022

DOI=10.3389/fneur.2019.01022

ISSN=1664-2295

ABSTRACT=LDH model shows a behavioural and biochemical alterations that in accordance with the characteristic of commorbity of pain and depression and FLX improve depressive behavior and alleviate pain through increased 5-HT concentration and inhibited TNF-α mRNA expression in this model.