AUTHOR=Yang Pei-Lin , Ward Teresa M. , Burr Robert L. , Kapur Vishesh K. , McCurry Susan M. , Vitiello Michael V. , Hough Catherine L. , Parsons Elizabeth C. 

TITLE=Sleep and Circadian Rhythms in Survivors of Acute Respiratory Failure

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00094

DOI=10.3389/fneur.2020.00094

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Little is known about sleep and circadian rhythms in survivors of acute respiratory failure (ARF) after hospital discharge.</p><p><bold>Objectives:</bold> To examine sleep and rest-activity circadian rhythms in ARF survivors 3 months after hospital discharge, and to compare them with a community-dwelling population.</p><p><bold>Methods:</bold> Sleep diary, actigraphy data, and insomnia symptoms were collected in a pilot study of 14 ARF survivors. Rest-activity circadian rhythms were assessed with wrist actigraphy and sleep diary for 9 days, and were analyzed by cosinor and non-parametric circadian rhythm analysis.</p><p><bold>Results:</bold> All participants had remarkable actigraphic sleep fragmentation, 71.5% had subclinical or clinical insomnia symptoms. Compared to community-dwelling adults, this cohort had less stable rest-activity circadian rhythms (<italic>p</italic> &lt; 0.001), and weaker circadian strength (<italic>p</italic> &lt; 0.001).</p><p><bold>Conclusion:</bold> Insomnia and circadian disruption were common in ARF survivors. Sleep improvement and circadian rhythm regularity may be a promising approach to improve quality of life and daytime function after ARF.</p>