AUTHOR=Pinggera Daniel , Luger Markus , Bürgler Iris , Bauer Marlies , Thomé Claudius , Petr Ondra TITLE=Safety of Early MRI Examinations in Severe TBI: A Test Battery for Proper Patient Selection JOURNAL=Frontiers in Neurology VOLUME=Volume 11 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00219 DOI=10.3389/fneur.2020.00219 ISSN=1664-2295 ABSTRACT=Introduction Early magnetic resonance imaging (MRI) provides indispensable information for management and prognosis in patients with severe traumatic brain injury (sTBI). Yet, optimal timing of MRI remains unknown. The aim of our study was to evaluate the safety of early MRI and to identify a method for appropriate patient selection to minimize adverse events related to the intrahospital transport (IHT) and the MRI examination. Methods Twenty-six patients with sTBI (mean GCS 6, range 3-8) admitted to our neurosurgical ICU from 03/ 2015 to 12/2017 and receiving at least one MRI within the first 14 days after initial traumatic event, were prospectively included in the study. The following requirements were fulfilled for at least 4 hours prior to anticipated MRI: MAP>70 mmHg, aPCO2 30-40mmHg, stable ICP<25mmHg. All relevant cardiopulmonary and cerebral parameters and medication were recorded. The following MRI sequences were performed: DWI, FLAIR, 3D T2-space, 3D T1 MPRAGE, 3D SWI, 3D TOF, pASL and 1H/31P-MRS. Results Four females and 22 males (aged 23–78years, mean 46.4years) with a median GCS on admission of 5 (range 3-8) were analyzed. In total, 40 IHTs were performed within the first 14 days (mean 6d, range 1-14d). Mean pre-MRI ICP was 14.1 mmHg (range 3-32mmHg). The mean post-MRI ICP was 14.3mmHg (range 3-29mmHg), decreasing to a mean ICP of 13.2mmHg after one hour (range 3-29mmHg). There were no significant differences in ICP measurements before and after MRI (p=0.30). MAP remained stable with no significant changes during the entire IHT and MRI. No other adverse events were observed as well. Conclusion Early MRI in acute severe TBI is feasible and safe. Yet, careful patient selection with prior adequate testing of cardiopulmonary and cerebral parameters is crucial to minimize transport- or examination-related morbidity.