AUTHOR=Nawabi Jawed , Kniep Helge , Kabiri Reza , Broocks Gabriel , Faizy Tobias D. , Thaler Christian , Schön Gerhard , Fiehler Jens , Hanning Uta TITLE=Neoplastic and Non-neoplastic Acute Intracerebral Hemorrhage in CT Brain Scans: Machine Learning-Based Prediction Using Radiomic Image Features JOURNAL=Frontiers in Neurology VOLUME=Volume 11 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00285 DOI=10.3389/fneur.2020.00285 ISSN=1664-2295 ABSTRACT=Background: Early differentiation of neoplastic and non-neoplastic intracerebral hemorrhage (ICH) can be difficult in initial radiological evaluation, especially for extensive ICH. The aim of this study was to evaluate the potential of a machine learning based prediction of etiology for acute ICHs based on quantitative radiomic image features extracted from initial noncontrast-enhanced computed tomography (NECT) brain scans. Materials and Methods: The analysis included NECT brain scans from 77 patients with acute ICH (n=50 non-neoplastic, n=27 neoplastic). Radiomic features including shape, histogram and texture markers were extracted from non- , wavelet- and log-sigma-filtered images using regions of interest of ICH and perihematomal edema (PHE). 6090 quantitative predictors were evaluated utilizing random forest algorithms with 5-fold model-external cross-validation. Model stability was assessed through comparative analysis of 10 randomly drawn cross-validation sets. Classifier performance was compared with predictions of two radiologists employing Matthews correlation coefficient (MCC). Results: ROC AUC of the test sets for predicting neoplastic vs. non-neoplastic ICHs was 0.89 (95% CI [0.70; 0.99]; P<0.001), specificities and sensitivities reached > 80%. Compared to the radiologists’ predictions, the machine learning algorithm yielded equal or superior results for all evaluated metrics. MCC of the proposed algorithm at its optimal operating point (0.69) was significantly higher than MCC of the radiologist readers (0.54); P =0.01. Conclusion: Evaluating quantitative features of acute NECT images in a machine learning algorithm provided high discriminatory power in predicting non-neoplastic vs. neoplastic ICHs. Utilized in clinical routine, the proposed approach could improve patient care at low risk and costs.