AUTHOR=Feng Hao , Wang Xin , Wang Wenjuan , Zhao Xingquan 

TITLE=Association Between Non-high-density Lipoprotein Cholesterol and 3-Month Prognosis in Patients With Spontaneous Intracerebral Hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00920

DOI=10.3389/fneur.2020.00920

ISSN=1664-2295

ABSTRACT=Background: Several studies have indicated a significant correlation between cholesterol levels and the incidence and outcomes of intracerebral hemorrhage (ICH), However, non-high-density lipoprotein cholesterol (non-HDLC) levels and functional outcomes of ICH are still unknown. 
Method: We included 654 consecutive patients from a prospective spontaneous ICH cohort. Clinical, demographic, and laboratory data were captured, and non-HDLC levels and 3-month modified Rankin Scale (mRS) scores were recorded. Using a multivariate model, we performed association and interaction analyses of the relationships between non-HDLC levels, and functional outcomes of ICH.
Results: Out of 654 patients, 281 (42.9%) had poor functional outcomes. Univariate analysis showed that a high non-HDLC level is an independent indicator for good functional outcome (p=0.001). After adjustment for confounding factors, high non-HDLC (≥154.89 mg/dl) remained as an indicator of good 90-day functional outcome (multivariate-adjusted odds ratios (OR) 0.50, 95%CI 0.27–0.92; p-value for trend = 0.043), especially for female patients (OR: 0.13, 95%CI: 0.03-0.50). 
Conclusion: ICH patients with higher non-HDLC levels had a decreased prevalence of poor outcomes, and low non-HDLC level is an independent indicator of poor functional outcome at 90 days from onset, especially in females.