AUTHOR=Zhou Yangyang , Wu Xinzhi , Tian Zhongbin , Yang Xinjian , Mu Shiqing 

TITLE=Pipeline Embolization Device With Adjunctive Coils for the Treatment of Unruptured Large or Giant Vertebrobasilar Aneurysms: A Single-Center Experience

JOURNAL=Frontiers in Neurology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.522583

DOI=10.3389/fneur.2020.522583

ISSN=1664-2295

ABSTRACT=Objective: To evaluate effectiveness and safety of Pipeline embolization device(PED) for large or giant verterbrobasilar aneurysms (LGVBAs), and to compare the therapeutic effects of PED with and without adjunctive coils.
Methods: We retrospectively analyzed 21 cases of unruptured LGVBAs who were treated in our hospital with PED. These cases were divided into ‘PED group’ and ‘PED with adjunctive coils group’. We compared the aneurysm characteristics and treatment outcomes between the two groups.
Results: The overall neurological complication rate was 33.3% (7/21) and the mortality rate was 4.8% (1/21). There were 12 patients in the PED group and nine in the PED with adjunctive coils group. There were no significant differences in age, smoking, hypertension, aneurysm size, aneurysm location, or operation time between the two groups. The complete aneurysm embolization rate and favorable outcome rate (modified Rankin Scale = 0,1) of the PED with adjunctive coils group was 78% (7/9) and 100% (9/9), respectively, which were both better compared with the PED group with 63.6% (7/11) and 83%(10/12), respectively. However, these differences were not statistically significant.
Conclusion: The effectiveness and safety of PED for LGVBAs is acceptable. The treatment results of the PED with adjunctive coils group were better than those of the PED group, although this difference was not significant. We suggest that PED with adjunctive coils should be used for some LGVBA patients.