AUTHOR=Wu Zhimin , Xiong Senjie , Sun Xiaochuan , Shi Quanhong , Dan Wei , Zhan Yan , Xie Yanfeng , Jiang Li 

TITLE=Effects of Apolipoprotein E Polymorphism on Cerebral Oxygen Saturation After Traumatic Brain Injury

JOURNAL=Frontiers in Neurology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.539627

DOI=10.3389/fneur.2020.539627

ISSN=1664-2295

ABSTRACT=Objective: To investigate the effect of the apolipoprotein E gene (APOE) on cerebral oxygen saturation of patients after traumatic brain injury (TBI).  
Methods: Clinical data of 114 patients with TBI and 54 normal people were collected, and the APOE genotypes of all subjects were determined by multiple quantitative fluorescent polymerase chain reaction (QF-PCR). The regional cerebral oxygen saturation (rScO2) of TBI patients and normal people were monitored by Near-infrared spectroscopy (NIRS). 
Results: The mean rScO2 of patients was (55.06±7.60)% in the early stage of TBI, which was significantly lower than that of normal people (67.21±7.80)% (P <0.05). Single-factor and multi-factor logic analysis showed APOEε4 was independent risk factors that caused the early decline of rScO2 in TBI patients. Furthermore, in the TBI group, the rScO2 of APOEε4 carriers (52.23±8.02)% was significantly lower than that of non-ε4 carriers (60.33±7.12)% (P<0.05). But in the normal group, no significant differences of rScO2 were found between APOEε4 carriers and non-carriers. 
Conclusion: The rScO2 of patients was significantly decreased after TBI, and APOEε4 may be a risk factor for decreased brain oxygen saturation in the early stage of TBI.