AUTHOR=Fu Xiongjie , Zhou Guoyang , Zhuang Jianfeng , Xu Chaoran , Zhou Hang , Peng Yucong , Cao Yang , Zeng Hanhai , Li Jianru , Yan Feng , Wang Lin , Chen Gao 

TITLE=White Matter Injury After Intracerebral Hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.562090

DOI=10.3389/fneur.2021.562090

ISSN=1664-2295

ABSTRACT=Spontaneous intracerebral hemorrhage (ICH) accounts for 15% of all strokes. ICH is a devastating form stroke associated with high morbidity, mortality and disability. Pre-clinical studies have explored the mechanisms of neuronal death and gray matter damage after ICH. But few studies have examined the development of white matter injury (WMI) following ICH. Research on WMI indicates that its pathophysiological presentation involves axonal damage, demyelination and mature oligodendrocytes loss. However, the detailed relationship and mechanism between WMI and ICH have remained unclear. Studies of other acute brain insults indicate that WMI is strongly correlated with cognitive deficits, neurological deficits and depression. The degreed of white matter injury determines the short and long-term prognosis of patients with ICH. This review illustrates the construction and functions of white matter in the healthy brain and discusses the pathophysiological mechanism of WMI following ICH. Our review demonstrates that the development of WMI after ICH is complex, therefore, comprehensive treatment is necessary. Understanding the relationship between WMI and other brain cells may reveal therapeutic targets for the treatment of ICH.